Background SPOUT methyltransferases (MTases) are a large class of S-adenosyl-L-
methionine-dependent enzymes that exhibit an unusual alpha/beta fold with a very deep …

Background Computational models of protein structure are usually inaccurate and exhibit
significant deviations from the true structure. The utility of models depends on the degree of …

This review presents the advances in protein structure prediction from the computational
methods perspective. The approaches are classified into four major categories: comparative …

Abstract Multiple Mapping Method with Multiple Templates (M4T)(http://www. fiserlab.
org/servers/m4t) is a fully automated comparative protein structure modeling server. The …

BUD23 was identified from a bioinformatics analysis of Saccharomyces cerevisiae genes
involved in ribosome biogenesis. Deletion of BUD23 leads to severely impaired growth …

The accuracy of a homology model based on the structure of a distant relative or other
topologically equivalent protein is primarily limited by the quality of the alignment. Here we …

For a very long time, Type II restriction enzymes (REases) have been a paradigm of
ORFans: proteins with no detectable similarity to each other and to any other protein in the …

With each round of CASP (Critical Assessment of Techniques for Protein Structure
Prediction), automated prediction servers have played an increasingly important role. Today …

Motivation: Two major bottlenecks in advancing comparative protein structure modeling are
the efficient combination of multiple template structures and the generation of a correct input …

Brr2 is a unique DExD/H box protein required for catalytic activation and disassembly of the
spliceosome. It contains two tandem helicase cassettes that both comprise dual RecA-like …