Hirschsprung disease
L Montalva, LS Cheng, R Kapur, JC Langer… - Nature Reviews …, 2023 - nature.com
Hirschsprung disease (HSCR) is a rare congenital intestinal disease that occurs in 1 in
5,000 live births. HSCR is characterized by the absence of ganglion cells in the myenteric …
5,000 live births. HSCR is characterized by the absence of ganglion cells in the myenteric …
Enteric nervous system development: A crest cell's journey from neural tube to colon
N Nagy, AM Goldstein - Seminars in cell & developmental biology, 2017 - Elsevier
The enteric nervous system (ENS) is comprised of a network of neurons and glial cells that
are responsible for coordinating many aspects of gastrointestinal (GI) function. These cells …
are responsible for coordinating many aspects of gastrointestinal (GI) function. These cells …
Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma
Intermittent intense ultraviolet (UV) exposure represents an important aetiological factor in
the development of malignant melanoma. The ability of UV radiation to cause tumour …
the development of malignant melanoma. The ability of UV radiation to cause tumour …
[HTML][HTML] In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains
The creation of molecular tools able to unravel in vivo spatiotemporal activation of specific
cell signaling events during cell migration, differentiation and morphogenesis is of great …
cell signaling events during cell migration, differentiation and morphogenesis is of great …
The science of Hirschsprung disease: what we know and where we are headed
JL Mueller, AM Goldstein - Seminars in pediatric surgery, 2022 - Elsevier
The enteric nervous system (ENS) is a rich network of neurons and glial cells that comprise
the gastrointestinal tract's intrinsic nervous system and are responsible for controlling …
the gastrointestinal tract's intrinsic nervous system and are responsible for controlling …
Development and developmental disorders of the enteric nervous system
F Obermayr, R Hotta, H Enomoto… - Nature reviews …, 2013 - nature.com
The enteric nervous system (ENS) arises from neural crest-derived cells that migrate into
and along the gut, leading to the formation of a complex network of neurons and glial cells …
and along the gut, leading to the formation of a complex network of neurons and glial cells …
Tumor neovascularization and developments in therapeutics
Y Katayama, J Uchino, Y Chihara, N Tamiya, Y Kaneko… - Cancers, 2019 - mdpi.com
Tumors undergo fast neovascularization to support the rapid proliferation of cancer cells.
Vasculature in tumors, unlike that in wound healing, is immature and affects the tumor …
Vasculature in tumors, unlike that in wound healing, is immature and affects the tumor …
Building a brain in the gut: development of the enteric nervous system
AM Goldstein, RMW Hofstra, AJ Burns - Clinical genetics, 2013 - Wiley Online Library
The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal tract, is an
essential component of the gut neuromusculature and controls many aspects of gut function …
essential component of the gut neuromusculature and controls many aspects of gut function …
Collagen, stiffness, and adhesion: the evolutionary basis of vertebrate mechanobiology
VW Tang - Molecular biology of the cell, 2020 - Am Soc Cell Biol
The emergence of collagen I in vertebrates resulted in a dramatic increase in the stiffness of
the extracellular environment, supporting long-range force propagation and the …
the extracellular environment, supporting long-range force propagation and the …
Enhancer variants synergistically drive dysfunction of a gene regulatory network in Hirschsprung disease
Common sequence variants in cis-regulatory elements (CREs) are suspected etiological
causes of complex disorders. We previously identified an intronic enhancer variant in the …
causes of complex disorders. We previously identified an intronic enhancer variant in the …