Hirschsprung disease

L Montalva, LS Cheng, R Kapur, JC Langer… - Nature Reviews …, 2023 - nature.com
Hirschsprung disease (HSCR) is a rare congenital intestinal disease that occurs in 1 in
5,000 live births. HSCR is characterized by the absence of ganglion cells in the myenteric …

Enteric nervous system development: A crest cell's journey from neural tube to colon

N Nagy, AM Goldstein - Seminars in cell & developmental biology, 2017 - Elsevier
The enteric nervous system (ENS) is comprised of a network of neurons and glial cells that
are responsible for coordinating many aspects of gastrointestinal (GI) function. These cells …

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma

T Bald, T Quast, J Landsberg, M Rogava, N Glodde… - Nature, 2014 - nature.com
Intermittent intense ultraviolet (UV) exposure represents an important aetiological factor in
the development of malignant melanoma. The ability of UV radiation to cause tumour …

[HTML][HTML] In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains

E Moro, G Ozhan-Kizil, A Mongera, D Beis… - Developmental …, 2012 - Elsevier
The creation of molecular tools able to unravel in vivo spatiotemporal activation of specific
cell signaling events during cell migration, differentiation and morphogenesis is of great …

The science of Hirschsprung disease: what we know and where we are headed

JL Mueller, AM Goldstein - Seminars in pediatric surgery, 2022 - Elsevier
The enteric nervous system (ENS) is a rich network of neurons and glial cells that comprise
the gastrointestinal tract's intrinsic nervous system and are responsible for controlling …

Development and developmental disorders of the enteric nervous system

F Obermayr, R Hotta, H Enomoto… - Nature reviews …, 2013 - nature.com
The enteric nervous system (ENS) arises from neural crest-derived cells that migrate into
and along the gut, leading to the formation of a complex network of neurons and glial cells …

Tumor neovascularization and developments in therapeutics

Y Katayama, J Uchino, Y Chihara, N Tamiya, Y Kaneko… - Cancers, 2019 - mdpi.com
Tumors undergo fast neovascularization to support the rapid proliferation of cancer cells.
Vasculature in tumors, unlike that in wound healing, is immature and affects the tumor …

Building a brain in the gut: development of the enteric nervous system

AM Goldstein, RMW Hofstra, AJ Burns - Clinical genetics, 2013 - Wiley Online Library
The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal tract, is an
essential component of the gut neuromusculature and controls many aspects of gut function …

Collagen, stiffness, and adhesion: the evolutionary basis of vertebrate mechanobiology

VW Tang - Molecular biology of the cell, 2020 - Am Soc Cell Biol
The emergence of collagen I in vertebrates resulted in a dramatic increase in the stiffness of
the extracellular environment, supporting long-range force propagation and the …

Enhancer variants synergistically drive dysfunction of a gene regulatory network in Hirschsprung disease

S Chatterjee, A Kapoor, JA Akiyama, DR Auer, D Lee… - Cell, 2016 - cell.com
Common sequence variants in cis-regulatory elements (CREs) are suspected etiological
causes of complex disorders. We previously identified an intronic enhancer variant in the …