Microglia in physiology and disease

SA Wolf, H Boddeke… - Annual review of …, 2017 - annualreviews.org
As the immune-competent cells of the brain, microglia play an increasingly important role in
maintaining normal brain function. They invade the brain early in development, transform …

An inflammation-centric view of neurological disease: beyond the neuron

SD Skaper, L Facci, M Zusso, P Giusti - Frontiers in cellular …, 2018 - frontiersin.org
Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …

The role of microglia in retinal neurodegeneration: Alzheimer's disease, Parkinson, and glaucoma

AI Ramirez, R de Hoz, E Salobrar-Garcia… - Frontiers in aging …, 2017 - frontiersin.org
Microglia, the immunocompetent cells of the central nervous system (CNS), act as
neuropathology sensors and are neuroprotective under physiological conditions. Microglia …

Microglia: housekeeper of the central nervous system

JA Kabba, Y Xu, H Christian, W Ruan, K Chenai… - Cellular and molecular …, 2018 - Springer
Microglia, of myeloid origin, play fundamental roles in the control of immune responses and
the maintenance of central nervous system homeostasis. These cells, just like peripheral …

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

N Dudvarski Stankovic, M Teodorczyk, R Ploen… - Acta …, 2016 - Springer
Microglia are long-living resident immune cells of the brain, which secure a stable chemical
and physical microenvironment necessary for the proper functioning of the central nervous …

Functional polarization of neuroglia: implications in neuroinflammation and neurological disorders

MK Jha, WH Lee, K Suk - Biochemical pharmacology, 2016 - Elsevier
Recent neuroscience research has established the adult brain as a dynamic organ having a
unique ability to undergo changes with time. Neuroglia, especially microglia and astrocytes …

[HTML][HTML] Microglial implications in SARS-CoV-2 infection and COVID-19: Lessons from viral RNA neurotropism and possible relevance to Parkinson's disease

IO Awogbindin, B Ben-Azu, BA Olusola… - Frontiers in Cellular …, 2021 - frontiersin.org
Since December 2019, humankind has been experiencing a ravaging severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, the second coronavirus …

Early life stress, depression and Parkinson's disease: a new approach

E Dallé, MV Mabandla - Molecular brain, 2018 - Springer
This review aims to shed light on the relationship that involves exposure to early life stress,
depression and Parkinson's disease (PD). A systematic literature search was conducted in …

Affective immunology: where emotions and the immune response converge

F D'Acquisto - Dialogues in clinical neuroscience, 2017 - Taylor & Francis
Affect and emotion are defined as “an essential part of the process of an organism's
interaction with stimuli.” Similar to affect, the immune response is the “tool” the body uses to …

The involvement of neuroinflammation in the onset and progression of Parkinson's disease

A Jurcau, FL Andronie-Cioara… - International Journal of …, 2023 - mdpi.com
Parkinson's disease is a neurodegenerative disease exhibiting the fastest growth in
incidence in recent years. As with most neurodegenerative diseases, the pathophysiology is …