Continuous flow technology has played an undeniable role in enabling modern chemical
synthesis, whereby a myriad of reactions can now be performed with greater efficiency …

Reactive organometallic intermediates present a distinct opportunity for the creation of novel
carbon-carbon and carbon-heteroatom bonds. Whereas their utility in synthesis is well …

Continuous flow reactors have earned their place as an important technology in organic
synthesis, receiving increased interest in the past decade. The favorable heat and mass …

The continuous flow reaction of various aryl or heteroaryl bromides in toluene in the
presence of THF (1.0 equiv) with sec‐BuLi (1.1 equiv) provided at 25° C within 40 sec the …

Herein, we report a rapid, one-step synthesis of α-ketoacetals via electrophilic etherification
of α-alkoxy enolates and monoperoxyacetals. Methyl, primary, and secondary α-ketoacetals …

Aromatic ketones are important pharmaceutical intermediates, especially the pyridin-2-yl-
methanone motifs. Thus, synthetic methods for these compounds have gained extensive …

This review deals with C1 carbenoid chemistry, with a focus on lithium carbenoid species
generated in flash flow systems. Strict control of the temperature, residence time, and mixing …

This chapter will cover recent progresses in homologation reactions conducted under flow
conditions using diazo compounds, mainly diazomethane and lithium carbenoids. In …

有机化学 Page 1 有机化学 Chinese Journal of Organic Chemistry REVIEW * Corresponding
authors. E-mail: chaoliu@licp.cas.cn; liqunjin@zjut.edu.cn Received January 19, 2022; …

Carboxylic esters are widely obtained, low-cost and readily available. Their conversions
have attracted widespread attention. Ketones are important synthetic intermediates, which …