Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …

Cellular senescence, an irreversible cell-cycle arrest, reflects a safeguard program that limits
the proliferative capacity of the cell exposed to endogenous or exogenous stress signals. A …

Cancer is one of the most serious diseases endangering human health. In view of the side
effects caused by chemotherapy and radiotherapy, it is necessary to develop low-toxic anti …

Induction of senescence has been proposed as a possible in vivo tumor response to
anticancer treatment. Senescent cancer cells are often polyploid, however, their route to …

Previous experiments have shown that curcumin or cisplatin treatment suppresses growth of
head and neck squamous cell carcinoma (HNSCC). To study the potential cooperative effect …

Myelination is a recent evolutionary addition that significantly enhances the speed of
transmission in the neural network. Even slight defects in myelin integrity impair …

An enhanced or abnormal inflammatory response to the lungs to inhaled particles and
gases, usually from cigarette smoke, is considered to be a general pathogenic mechanism …

Cellular senescence is a physiological process of irreversible cell-cycle arrest that
contributes to various physiological and pathological processes of aging. Whereas …

It is widely stated that wild-type p53 either mediates the activation of cell cycle checkpoints to
facilitate DNA repair and promote cell survival, or orchestrates apoptotic cell death following …

Classically, the development of emphysema in chronic obstructive pulmonary disease is
believed to involve inflammation induced by cigarette smoke and leukocyte activation …