Biological studies of post-traumatic stress disorder

RK Pitman, AM Rasmusson, KC Koenen… - nature Reviews …, 2012 - nature.com
Post-traumatic stress disorder (PTSD) is the only major mental disorder for which a cause is
considered to be known: that is, an event that involves threat to the physical integrity of …

Single-prolonged stress: a review of two decades of progress in a rodent model of post-traumatic stress disorder

MJ Lisieski, AL Eagle, AC Conti, I Liberzon… - Frontiers in …, 2018 - frontiersin.org
Post-traumatic stress disorder (PTSD) is a common, costly, and often debilitating psychiatric
condition. However, the biological mechanisms underlying this disease are still largely …

The traumatic stress response in child maltreatment and resultant neuropsychological effects

KR Wilson, DJ Hansen, M Li - Aggression and Violent Behavior, 2011 - Elsevier
Child maltreatment is a pervasive problem in our society that has long-term detrimental
consequences to the development of the affected child such as future brain growth and …

Animal models of PTSD: a critical review

EI Flandreau, M Toth - Behavioral Neurobiology of PTSD, 2018 - Springer
The goals of animal research in post-traumatic stress disorder (PTSD) include better
understanding the neurophysiological etiology of PTSD, identifying potential targets for …

Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine

M Möller, JL Du Preez, FP Viljoen, M Berk… - Brain, behavior, and …, 2013 - Elsevier
Apart from altered dopamine (DA) function, schizophrenia displays mitochondrial and
immune-inflammatory abnormalities, evidenced by oxidative stress, altered kynurenine …

Sampling blood from the lateral tail vein of the rat

G Lee, KA Goosens - Journal of visualized experiments: JoVE, 2015 - pmc.ncbi.nlm.nih.gov
Blood samples are commonly obtained in many experimental contexts to measure targets of
interest, including hormones, immune factors, growth factors, proteins, and glucose, yet the …

Alterations in monoamine levels and oxidative systems in frontal cortex, striatum, and hippocampus of the rat brain during chronic unpredictable stress

A Ahmad, N Rasheed, N Banu, G Palit - Stress, 2010 - Taylor & Francis
Stress plays a key role in the induction of various clinical disorders by altering
monoaminergic response and antioxidant defenses. In the present study, alterations in the …

Modelling posttraumatic stress disorders in animals

B Török, E Sipos, N Pivac, D Zelena - Progress in Neuro …, 2019 - Elsevier
Animal models of posttraumatic stress disorder are useful tools to reveal the neurobiological
basis of the vulnerability to traumatic events, and to develop new treatment strategies, as …

Strain differences in the neurochemical response to chronic restraint stress in the rat: relevance to depression

CM O'Mahony, G Clarke, S Gibney, TG Dinan… - Pharmacology …, 2011 - Elsevier
The neurochemical basis of depression focuses on alterations in the monoaminergic and
amino acid neurotransmitter systems. Moreover, decreases in serum levels of the …

Social stress during adolescence in Wistar rats induces social anxiety in adulthood without affecting brain monoaminergic content and activity

J Vidal, J de Bie, RA Granneman, AE Wallinga… - Physiology & …, 2007 - Elsevier
Adolescence has been described as an important period to acquire social competences
required for adult life. It has been suggested that early stress experiences could affect the …