Horizontal gene transfer and adaptive evolution in bacteria
Horizontal gene transfer (HGT) is arguably the most conspicuous feature of bacterial
evolution. Evidence for HGT is found in most bacterial genomes. Although HGT can …
evolution. Evidence for HGT is found in most bacterial genomes. Although HGT can …
Within-host evolution of bacterial pathogens
Whole-genome sequencing has opened the way for investigating the dynamics and
genomic evolution of bacterial pathogens during the colonization and infection of humans …
genomic evolution of bacterial pathogens during the colonization and infection of humans …
Emergence of methicillin resistance predates the clinical use of antibiotics
The discovery of antibiotics more than 80 years ago has led to considerable improvements
in human and animal health. Although antibiotic resistance in environmental bacteria is …
in human and animal health. Although antibiotic resistance in environmental bacteria is …
SARS-CoV-2 evolution during treatment of chronic infection
SA Kemp, DA Collier, RP Datir, IATM Ferreira, S Gayed… - Nature, 2021 - nature.com
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
critical for virus infection through the engagement of the human ACE2 protein and is a major …
critical for virus infection through the engagement of the human ACE2 protein and is a major …
SARS-CoV-2 within-host diversity and transmission
INTRODUCTION Genome sequencing at an unprecedented scale during the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is helping to track spread of …
respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is helping to track spread of …
Pandemic-scale phylogenomics reveals the SARS-CoV-2 recombination landscape
Accurate and timely detection of recombinant lineages is crucial for interpreting genetic
variation, reconstructing epidemic spread, identifying selection and variants of interest, and …
variation, reconstructing epidemic spread, identifying selection and variants of interest, and …
[HTML][HTML] Neutralising antibodies in Spike mediated SARS-CoV-2 adaptation
SA Kemp, DA Collier, R Datir, IATM Ferreira, S Gayed… - MedRxiv, 2020 - ncbi.nlm.nih.gov
SARS-CoV-2 Spike protein is critical for virus infection via engagement of ACE2, and amino
acid variation in Spike is increasingly appreciated. Given both vaccines and therapeutics are …
acid variation in Spike is increasingly appreciated. Given both vaccines and therapeutics are …
The global distribution and spread of the mobilized colistin resistance gene mcr-1
Colistin represents one of the few available drugs for treating infections caused by
carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of …
carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of …
Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide
The COVID-19 pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2), was declared on March 11, 2020 by the World Health Organization. As of the …
(SARS-CoV-2), was declared on March 11, 2020 by the World Health Organization. As of the …
Identification of Klebsiella capsule synthesis loci from whole genome data
Klebsiella pneumoniae is a growing cause of healthcare-associated infections for which
multi-drug resistance is a concern. Its polysaccharide capsule is a major virulence …
multi-drug resistance is a concern. Its polysaccharide capsule is a major virulence …