Specific immune responses are critically dependent on protein degradation products in the
form of peptides. These peptides are presented by major histocompatibility complexes …

This review is the fifth update of the original review, published in 1999, on the application of
MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings …

Glycopeptides are extremely useful for basic research and clinical applications, but access
to structurally defined glycopeptides is limited by the difficulties in synthesizing this class of …

Molecular docking plays an important role in drug discovery as a tool for the structure-based
design of small organic ligands for macromolecules. Possible applications of docking are …

Introduction Type II collagen is a DR4/DR1 restricted target of self-reactive T cells that
sustain rheumatoid arthritis. The aim of the present study was to analyze the T-cell receptor …

The ability to chemically alter proteins is important for broad areas of chemical biology,
biophysics, and medicine. Chemical catalysts for protein modification, and particularly …

The first total synthesis of asperphenins A and B has been accomplished in a concise, highly
stereoselective fashion from commercially available materials (15 steps, 9.7% and 14.2 …

The glycopeptide fragment CII259–273 from type II collagen (CII) binds to the murine Aq and
human DR4 class II Major Histocompatibility Complex (MHC II) proteins, which are …

The glycopeptide CII259-273, a fragment from type II collagen (CII), can induce tolerance in
mice susceptible to collagen-induced arthritis (CIA), which is a validated disease model for …

The structural basis for antigen presentation by class II major histocompatibility complex
(MHC) proteins to CD4+ T-cells is important for understanding and possibly treating …