Feedback regulation and coordination of the main metabolism for bacterial growth and metabolic engineering for amino acid fermentation
K Shimizu, Y Matsuoka - Biotechnology Advances, 2022 - Elsevier
Living organisms such as bacteria are often exposed to continuous changes in the nutrient
availability in nature. Therefore, bacteria must constantly monitor the environmental …
availability in nature. Therefore, bacteria must constantly monitor the environmental …
Acetate metabolism regulation in Escherichia coli: carbon overflow, pathogenicity, and beyond
Acetate is ubiquitously found in natural environments. Its availability in the gut is high as a
result of the fermentation of nutrients, and although it is rapidly absorbed by intestinal …
result of the fermentation of nutrients, and although it is rapidly absorbed by intestinal …
Suboptimal resource allocation in changing environments constrains response and growth in bacteria
To respond to fluctuating conditions, microbes typically need to synthesize novel proteins.
As this synthesis relies on sufficient biosynthetic precursors, microbes must devise effective …
As this synthesis relies on sufficient biosynthetic precursors, microbes must devise effective …
Ribosome-binding antibiotics increase bacterial longevity and growth efficiency
E Wood, H Schulenburg, P Rosenstiel… - Proceedings of the …, 2023 - National Acad Sciences
Antibiotics, by definition, reduce bacterial growth rates in optimal culture conditions;
however, the real-world environments bacteria inhabit see rapid growth punctuated by …
however, the real-world environments bacteria inhabit see rapid growth punctuated by …
Laboratory evolution to alternating substrate environments yields distinct phenotypic and genetic adaptive strategies
TE Sandberg, CJ Lloyd, BO Palsson… - Applied and …, 2017 - Am Soc Microbiol
Adaptive laboratory evolution (ALE) experiments are often designed to maintain a static
culturing environment to minimize confounding variables that could influence the adaptive …
culturing environment to minimize confounding variables that could influence the adaptive …
Bacterial glycogen provides short-term benefits in changing environments
Changing nutritional conditions challenge microbes and shape their evolutionary
optimization. Here, we used real-time metabolomics to investigate the role of glycogen in the …
optimization. Here, we used real-time metabolomics to investigate the role of glycogen in the …
Bacterial acetate metabolism and its influence on human epithelia
J Hosmer, AG McEwan, U Kappler - Emerging topics in life …, 2023 - portlandpress.com
Short-chain fatty acids are known modulators of host–microbe interactions and can affect
human health, inflammation, and outcomes of microbial infections. Acetate is the most …
human health, inflammation, and outcomes of microbial infections. Acetate is the most …
Distinct mechanisms coordinate transcription and translation under carbon and nitrogen starvation in Escherichia coli
Bacteria adapt to environmental stress by producing proteins that provide stress protection.
However, stress can severely perturb the kinetics of gene expression, disrupting protein …
However, stress can severely perturb the kinetics of gene expression, disrupting protein …
Comparison of glucose, acetate and ethanol as carbon resource for production of poly (3-hydroxybutyrate) and other acetyl-CoA derivatives
Poly (3-hydroxybutyrate)(PHB) is a biodegradable and biocompatible thermoplastic, and
synthesized from the central metabolite acetyl-CoA. The acetyl-CoA synthesis from glucose …
synthesized from the central metabolite acetyl-CoA. The acetyl-CoA synthesis from glucose …
Metabolic models of human gut microbiota: Advances and challenges
The human gut is a complex ecosystem consisting of hundreds of microbial species
interacting with each other and with the human host. Mathematical models of the gut …
interacting with each other and with the human host. Mathematical models of the gut …