Recent advances in the approval and commercialization of gene therapeutics have fostered
the return of gene therapy to center stage. But despite new optimism, no Food and Drug …

Bone defects and improper healing of fractures are an increasing public health burden, and
there is an unmet clinical need in their successful repair. Gene therapy has been proposed …

Gene therapy focuses on the genetic modification of cells, to produce a therapeutic effect or
for the treatment of disease, by repairing or reconstructing defective genetic material. The …

Tendon and ligament injuries have always been complex to treat, with recovery often taking
many months, if successful at all. This chapter looks at recent work undertaken using …

The load-bearing tissues such as bone, cartilage, and the osteochondral interface perform a
pivotal role in the biomechanical support and routine activities of the human body. These …

The number of studies related with gene-activated matrices is increasing annually; the first-
in-class product has been already implemented into clinical practice for bone grafting …

Количество исследований в области ген-активированных материалов ежегодно
увеличивается, первое изделие данного класса уже внедрено в клиническую практику …

Genomic regions determining sexual compatibility often display recombination suppression,
as occurs in sex chromosomes, plant self-incompatibility loci and fungal mating-type loci …

Введение. Лечение пациентов с ложными суставами длинных трубчатых костей до
настоящего времени остается сложной клинической проблемой. Замедленно …

Firstly, it is important to understand that there is currently only one approved gene plasmid-
based therapy on the world market. Indeed several authors in the Deev et al. paper actively …