Tracking the progeny of single cells is necessary for building lineage trees that recapitulate
processes such as embryonic development and stem cell differentiation. In classical lineage …

Every animal grows from a single fertilized egg into an intricate network of cell types and
organ systems. This process is captured in a lineage tree: a diagram of every cell's ancestry …

Delineating the gene-regulatory programs underlying complex cell types is fundamental for
understanding brain function in health and disease. Here, we comprehensively examined …

Background DNA methylation (DNAm) is an epigenetic regulator of gene expression
programs that can be altered by environmental exposures, aging, and in pathogenesis …

The dynamical process of cell division that underpins homeostasis in the human body
cannot be directly observed in vivo, but instead is measurable from the pattern of somatic …

Background Non-muscle-invasive bladder cancer (NMIBC) patients receive frequent
monitoring because≥ 70% will have recurrent disease. However, screening is invasive …

Introduction The human brain comprises heterogeneous cell types whose composition can
be altered with physiological and pathological conditions. New approaches to discern the …

Aging is a significant risk factor for various human disorders, and DNA methylation clocks
have emerged as powerful tools for estimating biological age and predicting health‐related …

Health disparities correspond to differences in disease burden and mortality among socially
defined population groups. Such disparities may emerge according to race/ethnicity …

Down syndrome (DS) is a genetic disorder caused by an extra copy of chromosome 21 that
presents developmental dysfunction and intellectual disability. To better understand the …