Inflammasomes are macromolecular platforms formed in response to damage-associated
molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation …

Breast cancer is the most diagnosed malignancy in women. Increasing evidence has
highlighted the importance of chronic inflammation at the local and/or systemic level in …

The function of mitophagy in cancer is controversial. ULK1 is critical for induction of
macroautophagy/autophagy and has a more specific role in mitophagy in response to …

Water pollution caused by widely used agricultural pesticide chlorpyrifos (CPF) has aroused
extensive public concern. While previous studies have reported on toxic effect of CPF on …

Immune checkpoint blockade (ICB) is a powerful approach for cancer therapy although good
responses are only observed in a fraction of cancer patients. Breast cancers caused by …

Natural products perennially serve as prolific sources of drug leads and chemical probes,
fueling the development of numerous therapeutics. Despite their scarcity, natural products …

Chinese herb Radix sophorae tonkinensis extract oxymatrine shows anticancer effects. This
study evaluated the role of oxymatrine in colorectal cancer (CRC) and the underlying …

Breast cancer is still one of the most common malignancies worldwide and remains a major
clinical challenge. We previously reported that the anthelmintic drug flubendazole induced …

Mercury (Hg) is a persistent heavy metal contaminant with definite hepatotoxicity. Selenium
(Se) has been shown to alleviate liver damage induced by heavy metals. Therefore, the …

Reactive oxygen species (ROS) are generally small, short-lived and highly reactive
molecules, initially thought to be a pathological role in the cell. A growing amount of …