Traditional methods of localizing and quantifying the presence of pathogenic
microorganisms in living experimental animal models of infections have mostly relied on …

During the 1980s, many kinetoplastid genes were cloned and their function inferred from
homology with genes from other organisms, location of the corresponding proteins or …

Autophagy is the major mechanism used by eukaryotic cells to degrade and recycle proteins
and organelles. Bioinformatics analysis of the genome of the protozoan parasite …

TcP2β ribosomal protein genes in Trypanosoma cruzi are encoded by four different loci, H6.
4, H1. 8, H1. 5 and H1. 3. All loci have a similar organization, except for H1. 8 that harbors …

Trypanosoma cruzi has a complex mucin gene family of 500 members with hypervariable
regions expressed preferentially in vertebrate associated stages of the parasite. In this work …

Trypanosoma cruziglutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid,
phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which …

This report describes the construction of a DNA cassette for integration into a genomic small
sub-unit rRNA locus of Leishmania mexicana by homologous recombination. Reporter …

To improve transfection efficiency in Trypanosoma cruzi, we developed a new
electroporation protocol and expression vectors which use luciferase and green and red …

Trypanosoma cruzi, the causative agent of Chagas disease (CD), contains exclusively Fe-
dependent superoxide dismutases (Fe-SODs). During T. cruzi invasion to macrophages …

Novel technologies that include recombinant pathogens and rapid detection methods are
contributing to the development of drugs for neglected diseases. Recently, the results from …