Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …

Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Highly ordered organisation of striated muscle is the prerequisite for the fast and
unidirectional development of force and motion during heart and skeletal muscle …

During postnatal cardiac development, cardiomyocytes mature and turn into adult ones.
Hence, all cellular properties, including morphology, structure, physiology and metabolism …

Cardiac muscle cells are equipped with specialized biochemical machineries for the rapid
generation of force and movement central to the work generated by the heart. During each …

Cardiomyocytes (CMs) are terminally differentiated cells in the adult heart, and ischemia and
cardiotoxic compounds can lead to cell death and irreversible decline of cardiac function. As …

The sarcomere is the basic unit of the myofibrils, which mediate skeletal and cardiac Muscle
contraction. Two transverse structures, the Z-disc and the M-band, anchor the thin (actin and …

In striated muscle sarcomeres, the contractile actin and myosin filaments are organised by a
subset of specialised cytoskeletal proteins, the sarcomeric cytoskeleton. They include α …

We describe a conditional in vivo protein-trap mutagenesis system that reveals
spatiotemporal protein expression dynamics and can be used to assess gene function in the …

Obscurin, a giant modular muscle protein implicated in G-protein and protein-kinase
signalling, can localize to both sarcomeric Z-disks and M-bands. Interaction of obscurin with …