Radiotherapy combined with immunotherapy: the dawn of cancer treatment

Z Zhang, X Liu, D Chen, J Yu - Signal Transduction and Targeted …, 2022 - nature.com
Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …

The crosstalk between tumor cells and the immune microenvironment in breast cancer: implications for immunotherapy

V Salemme, G Centonze, F Cavallo, P Defilippi… - Frontiers in …, 2021 - frontiersin.org
Breast cancer progression is a complex process controlled by genetic and epigenetic factors
that coordinate the crosstalk between tumor cells and the components of tumor …

Microneedles for painless transdermal immunotherapeutic applications

H Amani, MA Shahbazi, C D'Amico, F Fontana… - Journal of Controlled …, 2021 - Elsevier
Immunotherapy has recently garnered plenty of attention to improve the clinical outcomes in
the treatment of various diseases. However, owing to the dynamic nature of the immune …

Adaptive mechanisms of tumor therapy resistance driven by tumor microenvironment

P Wu, W Gao, M Su, EC Nice, W Zhang… - Frontiers in cell and …, 2021 - frontiersin.org
Cancer is a disease which frequently has a poor prognosis. Although multiple therapeutic
strategies have been developed for various cancers, including chemotherapy, radiotherapy …

Effects of chemotherapy on the immune system: implications for cancer treatment and patient outcomes

A Sharma, S Jasrotia, A Kumar - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
Chemotherapy is a cornerstone of cancer treatment, but it can also induce immune
suppression, which can have significant implications for patient outcomes. This review paper …

iPSC-derived natural killer cell therapies-expansion and targeting

BH Goldenson, P Hor, DS Kaufman - Frontiers in immunology, 2022 - frontiersin.org
Treatment of cancer with allogeneic natural killer (NK) cell therapies has seen rapid
development, especially use against hematologic malignancies. Clinical trials of NK cell …

Polymer micropatches as natural killer cell engagers for tumor therapy

S Prakash, N Kumbhojkar, A Lu, N Kapate, VC Suja… - ACS …, 2023 - ACS Publications
Natural killer (NK) cell therapies have emerged as a potential therapeutic approach to
various cancers. Their efficacy, however, is limited by their low persistence and anergy …

CAR-NK cells: from natural basis to design for kill

MB Khawar, H Sun - Frontiers in immunology, 2021 - frontiersin.org
Chimeric antigen receptors (CARs) are fusion proteins with an extracellular antigen
recognition domain and numerous intracellular signaling domains that have been …

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

M Chehelgerdi, F Behdarvand Dehkordi… - Molecular Cancer, 2023 - Springer
The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy

R Hosseini, H Sarvnaz, M Arabpour, SM Ramshe… - Molecular cancer, 2022 - Springer
Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is
now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity …