Asthma and chronic obstructive pulmonary disease are inflammatory lung disorders
responsible for significant morbidity and mortality worldwide. While the importance of …

Surface plasmon resonance (SPR) biosensors have enabled a wide range of applications in
which researchers can monitor biomolecular interactions in real time. Owing to the fact that …

Peptide nucleic acids (PNAs) are synthetic mimics of DNA in which the deoxyribose
phosphate backbone is replaced by a pseudo-peptide polymer to which the nucleobases …

Transfection of cis-element double-stranded oligonucleotides, referred to as decoy ODNs,
has been reported to be a powerful tool that provides a new class of antigene strategies for …

Non-small cell lung cancer (NSCLC) is among the leading global causes of cancer-related
mortality. Current treatment options have limited efficacy and severe adverse effects …

Nuclear factor κB (NFκB) is a unique protein complex that plays a major role in lung
inflammation and respiratory dysfunction. The NFκB signaling pathway, therefore becomes …

KRAS mutations are primary genetic lesions leading to pancreatic cancer. The promoter of
human KRAS contains a nuclease-hypersensitive element (NHE) that can fold in G4-DNA …

Peptide nucleic acid (PNA) and locked nucleic acid (LNA) oligomers bind to complementary
sequences with extremely high affinity. This high-affinity binding supports the hypothesis that …

In the past, surface plasmons have been used to improve the surface sensitivity of several
spectroscopic measurements. Surface plasmon resonance reflectivity measurements can be …

During the latest decades a number of different nucleic acid analogs containing natural
nucleobases on a modified backbone have been synthesized. An example of this is peptide …