The rediscovery and reinterpretation of the Warburg effect in the year 2000 occulted for
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …

Deregulated cellular energetics was one of the cancer hallmarks. Several underlying
mechanisms of deregulated cellular energetics are associated with mitochondrial …

The human mitochondrial genome is extremely small compared with the nuclear genome,
and mitochondrial genetics presents unique clinical and experimental challenges. Despite …

Human mitochondrial ribosomes are highly divergent from all other known ribosomes and
are specialized to exclusively translate membrane proteins. They are linked with hereditary …

It has been known for decades that it is possible to detect small amounts of extracellular
nucleic acids in plasma and serum of healthy and diseased human beings. The unequivocal …

Mutations in the mtDNA have been found to fulfill all of the criteria expected for pathogenic
mutations causing prostate cancer. Focusing on the cytochrome oxidase subunit I (COI) …

The metabolism of solid tumors is associated with high lactate production while growing in
oxygen (aerobic glycolysis) suggesting that tumors may have defects in mitochondrial …

Somatic mitochondrial DNA (mtDNA) mutations have been increasingly observed in primary
human cancers. As each cell contains many mitochondria with multiple copies of mtDNA, it …

Mitochondria play important roles in cellular energy metabolism, free radical generation, and
apoptosis. Defects in mitochondrial function have long been suspected to contribute to the …

Mitochondria, an eukaryotic organelle, is regarded as the most critical target since it
regulates several vital functions in cell physiology. It is the hub of metabolic activity and a …