Type 2 diabetes mellitus is characterized by the dysregulation of glucose homeostasis,
resulting in hyperglycaemia. Although current diabetes treatments have exhibited some …

Excessive sugar consumption and defective glucose sensing by hepatocytes contribute to
the development of metabolic diseases including type 2 diabetes mellitus (T2DM) and …

Beneficial effects of dietary fiber on glucose and energy homeostasis have long been
described, focusing mostly on the production of short-chain fatty acids by the gut commensal …

With the identification of ChREBP in 2001, our interest in understanding the molecular
control of carbohydrate sensing has surged. While ChREBP was initially studied as a master …

Results: In the liver, acetate decreased lipid accumulation and improved hepatic function, as
well as increasing mitochondrial efficiency. In white adipose tissue, it inhibited lipolysis and …

Intestinal gluconeogenesis is a recently identified function influencing energy homeostasis.
Intestinal gluconeogenesis induced by specific nutrients releases glucose, which is sensed …

Cells efficiently adjust their metabolism according to the abundance of nutrients and energy.
The ability to switch cellular metabolism between anabolic and catabolic processes is critical …

In the face of urbanisation, surplus energy intake, sedentary habits and obesity, type 2
diabetes has developed into a major health concern worldwide. Commonly overlooked in …

Light at night (LAN) negatively impacts the behaviour and physiology; however, very little is
known about molecular correlates of LAN-induced effects in diurnal animals. Here, we …

Myeloperoxidase (MPO) is positively associated with obesity and diet-induced insulin
resistance. Angiopoietin-like protein 6 (ANGPTL6) regulates metabolic processes and …