Spina Bifida | New England Journal of Medicine Skip to main content The New England Journal
of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology Clinical Medicine …

Integrated in vitro models of human organogenesis are needed to elucidate the multi-
systemic events underlying development and disease. Here we report the generation of …

Objective To provide updated guidance on pre-conception folic acid and multivitamin
supplementation for primary and secondary (recurrence) prevention of neural tube defects …

Orofacial clefts, including cleft lip and palate (CL/P) and neural tube defects (NTDs) are
among the most common congenital anomalies, but knowledge of the genetic basis of these …

Spina bifida (SB) is one of the most common birth defects in children. The care for patients
with SB continues to evolve, and there has been notable improvement in survival outcomes …

Neural tube defects (NTDs) are the second most common cause of congenital malformations
and are often studied in animal models. Loop-tail (Lp) mice carry a mutation in the Vangl2 …

Spina bifida (SB) is a debilitating birth defect caused by multiple gene and environment
interactions. Though SB shows non-Mendelian inheritance, genetic factors contribute to an …

Introduction: Neural tube defects (NTDs) are among the most debilitating and common
developmental defects in humans. The induction of NTDs has been attributed to abnormal …

Background Human studies of genetic risk factors for neural tube defects, severe birth
defects associated with long‐term health consequences in surviving children, have …

Neural tube defects (NTDs) are severe malformations of the central nervous system that
arise from failure of neural tube closure. HECTD1 is an E3 ubiquitin ligase required for …