ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

MRtrix3 is an open-source, cross-platform software package for medical image processing,
analysis and visualisation, with a particular emphasis on the investigation of the brain using …

The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

Diffusion MRI has provided the neuroimaging community with a powerful tool to acquire in-
vivo data sensitive to microstructural features of white matter, up to 3 orders of magnitude …

Diffusion magnetic resonance imaging (dMRI) tractography is an advanced imaging
technique that enables in vivo reconstruction of the brain's white matter connections at …

Alzheimer's disease (AD) is a degenerative neurological disease in elderly individuals.
Subjective cognitive decline (SCD), mild cognitive impairment (MCI) and further …

Diffusion MRI‐based tractography is the most commonly‐used technique when inferring the
structural brain connectome, ie, the comprehensive map of the connections in the brain. The …

Diffusion MRI tractography processing pipeline requires a large number of steps (typically
20+ steps). If parameters of these steps, number of threads, and random seed generators …

Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in
2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild …

White matter alterations are present in the majority of patients with Alzheimer's disease type
dementia. However, the spatiotemporal pattern of white matter changes preceding dementia …