Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

Pseudomonas aeruginosa is a major opportunistic pathogen, causing a wide range of acute
and chronic infections. β-lactam antibiotics including penicillins, carbapenems …

One of the most striking features of Pseudomonas aeruginosa is its outstanding capacity for
developing antimicrobial resistance to nearly all available antipseudomonal agents through …

Ceftazidime-avibactam is a combination of β-lactam/β-lactamase inhibitor, the use of which
is restricted to some clinical cases, including cystic fibrosis patients infected with multidrug …

Previous studies have demonstrated substantial genetic diversification of Pseudomonas
aeruginosa across sub-compartments in cystic fibrosis (CF) lungs. Here, we isolate P …

The antimicrobial resistance crisis is an ongoing major threat to public health safety. Low-
and middle-income countries are particularly susceptible to higher fatality rates and the …

At present, antibiotic resistance represents a global problem in modern medicine. In the near
future, humanity may face a situation where medicine will be powerless against resistant …

Pseudomonas aeruginosa exploits intrinsic and acquired resistance mechanisms to resist
almost every antibiotic used in chemotherapy. Antimicrobial resistance in P. aeruginosa …

Background β-lactam antibiotics, which inhibit penicillin-binding protein 3 (PBP3) that is
required for cell division, play a key role in treating P. aeruginosa infections. Some …

ABSTRACT The CDC's Emerging Infections Program (EIP) conducted population-and
laboratory-based surveillance of US carbapenem-resistant Pseudomonas aeruginosa …