Sepsis-associated acute kidney injury (S-AKI) is a frequent complication of the critically ill
patient and is associated with unacceptable morbidity and mortality. Prevention of S-AKI is …

Acute kidney injury (AKI) and sepsis carry consensus definitions. The simultaneous
presence of both identifies septic AKI. Septic AKI is the most common AKI syndrome in ICU …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Rationale: Exogenous angiotensin II increases mean arterial pressure in patients with
catecholamine-resistant vasodilatory shock (CRVS). We hypothesized that renin …

Background Vasodilatory shock that does not respond to high-dose vasopressors is
associated with high mortality. We investigated the effectiveness of angiotensin II for the …

Background Vasopressors are administered to critically ill patients with vasodilatory shock
not responsive to volume resuscitation, and less often in cardiogenic shock, and …

Refractory shock is a lethal manifestation of cardiovascular failure defined by an inadequate
hemodynamic response to high doses of vasopressor medications. Approximately 7% of …

Sepsis is a major growing global burden and a major challenge to intensive care clinicians,
researchers, guideline committee members and policy makers, because of its high and …

AKI is a common complication of sepsis and is significantly associated with mortality. Sepsis
accounts for more than 50% of the cases of AKI, with a mortality rate of up to 40%. The …

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