DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
DNA methylation clocks in aging: categories, causes, and consequences
Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …
thought to promote diseases of aging, such as cancer. Recent studies have identified …
Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states
Single-cell RNA sequencing has revealed extensive transcriptional cell state diversity in
cancer, often observed independently of genetic heterogeneity, raising the central question …
cancer, often observed independently of genetic heterogeneity, raising the central question …
The origin of highly elevated cell-free DNA in healthy individuals and patients with pancreatic, colorectal, lung, or ovarian cancer
AK Mattox, C Douville, Y Wang, M Popoli, J Ptak… - Cancer discovery, 2023 - AACR
Cell-free DNA (cfDNA) concentrations from patients with cancer are often elevated
compared with those of healthy controls, but the sources of this extra cfDNA have never …
compared with those of healthy controls, but the sources of this extra cfDNA have never …
An epigenetic role of mitochondria in cancer
Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …
Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma
R Xu, W Wei, M Krawczyk, W Wang, H Luo, K Flagg… - Nature materials, 2017 - nature.com
An effective blood-based method for the diagnosis and prognosis of hepatocellular
carcinoma (HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying …
carcinoma (HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying …
Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer
H Luo, Q Zhao, W Wei, L Zheng, S Yi, G Li… - Science translational …, 2020 - science.org
Circulating tumor DNA (ctDNA) has emerged as a useful diagnostic and prognostic
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …
Senescence mechanisms and targets in the heart
Cellular senescence is a state of irreversible cell cycle arrest associated with ageing.
Senescence of different cardiac cell types can direct the pathophysiology of cardiovascular …
Senescence of different cardiac cell types can direct the pathophysiology of cardiovascular …
The DNA methylation landscape in cancer
As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …
plays an essential role in normal development and cellular biology. Global alterations to the …
lncRNA epigenetic landscape analysis identifies EPIC1 as an oncogenic lncRNA that interacts with MYC and promotes cell-cycle progression in cancer
We characterized the epigenetic landscape of genes encoding long noncoding RNAs
(lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to the CpG island …
(lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to the CpG island …