Strategies to therapeutically modulate cytokine action
WJ Leonard, JX Lin - Nature Reviews Drug Discovery, 2023 - nature.com
Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …
functions, including development, differentiation, growth and survival. Accordingly, the …
Immunomodulation—a general review of the current state-of-the-art and new therapeutic strategies for targeting the immune system
M Strzelec, J Detka, P Mieszczak… - Frontiers in …, 2023 - frontiersin.org
In recent years, there has been a tremendous development of biotechnological,
pharmacological, and medical techniques which can be implemented in the functional …
pharmacological, and medical techniques which can be implemented in the functional …
[HTML][HTML] Engineering interferons and interleukins for cancer immunotherapy
Cytokines are a class of potent immunoregulatory proteins that are secreted in response to
various stimuli and act locally to regulate many aspects of human physiology and disease …
various stimuli and act locally to regulate many aspects of human physiology and disease …
The association of COVID-19 severity and susceptibility and genetic risk factors: A systematic review of the literature
A Ishak, M Mehendale, MM AlRawashdeh… - Gene, 2022 - Elsevier
Background COVID-19 is associated with several risk factors such as distinct ethnicities
(genetic ancestry), races, sexes, age, pre-existing comorbidities, smoking, and genetics. The …
(genetic ancestry), races, sexes, age, pre-existing comorbidities, smoking, and genetics. The …
Type III interferons: emerging roles in autoimmunity
S Manivasagam, RS Klein - Frontiers in immunology, 2021 - frontiersin.org
Type III interferons (IFNs) or the lambda IFNs (IFNLs or IFN-λs) are antimicrobial cytokines
that play key roles in immune host defense at endothelial and epithelial barriers. IFNLs …
that play key roles in immune host defense at endothelial and epithelial barriers. IFNLs …
Human leukocyte immunoglobulin-like receptors in health and disease
S Redondo-García, C Barritt, C Papagregoriou… - Frontiers in …, 2023 - frontiersin.org
Human leukocyte immunoglobulin (Ig)-like receptors (LILR) are a family of 11 innate
immunomodulatory receptors, primarily expressed on lymphoid and myeloid cells. LILRs are …
immunomodulatory receptors, primarily expressed on lymphoid and myeloid cells. LILRs are …
[HTML][HTML] Pre-infection antiviral innate immunity contributes to sex differences in SARS-CoV-2 infection
Male sex is a major risk factor for SARS-CoV-2 infection severity. To understand the basis for
this sex difference, we studied SARS-CoV-2 infection in a young adult cohort of United …
this sex difference, we studied SARS-CoV-2 infection in a young adult cohort of United …
B cells in systemic lupus erythematosus
B cells in systemic lupus erythematosus : Current Opinion in Rheumatology B cells in systemic
lupus erythematosus : Current Opinion in Rheumatology Log in or Register Subscribe to …
lupus erythematosus : Current Opinion in Rheumatology Log in or Register Subscribe to …
[HTML][HTML] COVID-19 outcomes in patients with dermatomyositis: a registry-based cohort analysis
H Pakhchanian, H Khan, R Raiker, S Ahmed… - Seminars in arthritis and …, 2022 - Elsevier
Background: Patients with rheumatic diseases (RDs) like DM are known to be vulnerable
towards various types of infections due to aggressive disease activity mandating high dose …
towards various types of infections due to aggressive disease activity mandating high dose …
Autoantibodies neutralizing type III interferons are uncommon in patients with severe coronavirus disease 2019 pneumonia
M Vanker, K Särekannu, A Fekkar… - Journal of Interferon & …, 2023 - liebertpub.com
Autoantibodies (AABs) neutralizing type I interferons (IFN) underlie about 15% of cases of
critical coronavirus disease 2019 (COVID-19) pneumonia. The impact of autoimmunity …
critical coronavirus disease 2019 (COVID-19) pneumonia. The impact of autoimmunity …