Mitochondrial DNA in inflammation and immunity

JS Riley, SWG Tait - EMBO reports, 2020 - embopress.org
Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …

[HTML][HTML] Intercellular mitochondrial transfer as a means of tissue revitalization

D Liu, Y Gao, J Liu, Y Huang, J Yin, Y Feng… - Signal transduction and …, 2021 - nature.com
As the crucial powerhouse for cell metabolism and tissue survival, the mitochondrion
frequently undergoes morphological or positional changes when responding to various …

[HTML][HTML] GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity

DC Watson, D Bayik, S Storevik, SS Moreino… - Nature cancer, 2023 - nature.com
The transfer of intact mitochondria between heterogeneous cell types has been confirmed in
various settings, including cancer. However, the functional implications of mitochondria …

[HTML][HTML] Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management

P Jin, J Jiang, L Zhou, Z Huang, EC Nice… - Journal of Hematology & …, 2022 - Springer
Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

[PDF][PDF] Intercellular mitochondria transfer to macrophages regulates white adipose tissue homeostasis and is impaired in obesity

JR Brestoff, CB Wilen, JR Moley, Y Li, W Zou… - Cell metabolism, 2021 - cell.com
Recent studies suggest that mitochondria can be transferred between cells to support the
survival of metabolically compromised cells. However, whether intercellular mitochondria …

[HTML][HTML] Mitochondrial metabolism and cancer

PE Porporato, N Filigheddu, JMBS Pedro, G Kroemer… - Cell research, 2018 - nature.com
Glycolysis has long been considered as the major metabolic process for energy production
and anabolic growth in cancer cells. Although such a view has been instrumental for the …

[HTML][HTML] Molecular mechanisms of mtDNA-mediated inflammation

A De Gaetano, K Solodka, G Zanini, V Selleri… - Cells, 2021 - mdpi.com
Besides their role in cell metabolism, mitochondria display many other functions.
Mitochondrial DNA (mtDNA), the own genome of the organelle, plays an important role in …

[HTML][HTML] The significance of mitochondrial dysfunction in cancer

Y Luo, J Ma, W Lu - International journal of molecular sciences, 2020 - mdpi.com
As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in
energy metabolism, maintenance of redox balance, and regulation of apoptosis …

[HTML][HTML] Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases

Z Liu, Y Sun, Z Qi, L Cao, S Ding - Cell & bioscience, 2022 - Springer
Mitochondria play a pivotal role in energy generation and cellular physiological processes.
These organelles are highly dynamic, constantly changing their morphology, cellular …

[HTML][HTML] Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs

K Todkar, L Chikhi, V Desjardins, F El-Mortada… - Nature …, 2021 - nature.com
Most cells constitutively secrete mitochondrial DNA and proteins in extracellular vesicles
(EVs). While EVs are small vesicles that transfer material between cells, Mitochondria …