[HTML][HTML] Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities

KD Davis, N Aghaeepour, AH Ahn, MS Angst… - Nature Reviews …, 2020 - nature.com
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …

Transition from acute to chronic pain after surgery

P Glare, KR Aubrey, PS Myles - The Lancet, 2019 - thelancet.com
Over the past decade there has been an increasing reliance on strong opioids to treat acute
and chronic pain, which has been associated with a rising epidemic of prescription opioid …

First-in-human prediction of chronic pain state using intracranial neural biomarkers

P Shirvalkar, J Prosky, G Chin, P Ahmadipour… - Nature …, 2023 - nature.com
Chronic pain syndromes are often refractory to treatment and cause substantial suffering
and disability. Pain severity is often measured through subjective report, while objective …

[HTML][HTML] The anatomy of pain and suffering in the brain and its clinical implications

D De Ridder, D Adhia, S Vanneste - Neuroscience & Biobehavioral …, 2021 - Elsevier
Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …

[HTML][HTML] Cellular circuits in the brain and their modulation in acute and chronic pain

R Kuner, T Kuner - Physiological reviews, 2020 - journals.physiology.org
Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …

[HTML][HTML] Role of the prefrontal cortex in pain processing

WY Ong, CS Stohler, DR Herr - Molecular neurobiology, 2019 - Springer
The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …

Resting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: A review and synthesis

I Sezer, DA Pizzagalli, MD Sacchet - Neuroscience & Biobehavioral …, 2022 - Elsevier
This review synthesizes relations between mindfulness and resting-state fMRI functional
connectivity of brain networks. Mindfulness is characterized by present-moment awareness …

The link between depression and chronic pain: neural mechanisms in the brain

J Sheng, S Liu, Y Wang, R Cui, X Zhang - Neural plasticity, 2017 - Wiley Online Library
Chronic pain, as a stress state, is one of the critical factors for determining depression, and
their coexistence tends to further aggravate the severity of both disorders. Unfortunately …

[HTML][HTML] Targeted muscle reinnervation treats neuroma and phantom pain in major limb amputees: a randomized clinical trial

GA Dumanian, BK Potter, LM Mioton, JH Ko… - 2019 - journals.lww.com
Objective: To compare targeted muscle reinnervation (TMR) to “standard treatment” of
neuroma excision and burying into muscle for postamputation pain. Summary Background …

[HTML][HTML] Chronic pain: structural and functional changes in brain structures and associated negative affective states

S Yang, MC Chang - International journal of molecular sciences, 2019 - mdpi.com
Chronic pain is a condition in which pain progresses from an acute to chronic state and
persists beyond the healing process. Chronic pain impairs function and decreases patients' …