[HTML][HTML] Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
Transition from acute to chronic pain after surgery
Over the past decade there has been an increasing reliance on strong opioids to treat acute
and chronic pain, which has been associated with a rising epidemic of prescription opioid …
and chronic pain, which has been associated with a rising epidemic of prescription opioid …
First-in-human prediction of chronic pain state using intracranial neural biomarkers
Chronic pain syndromes are often refractory to treatment and cause substantial suffering
and disability. Pain severity is often measured through subjective report, while objective …
and disability. Pain severity is often measured through subjective report, while objective …
[HTML][HTML] The anatomy of pain and suffering in the brain and its clinical implications
Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …
[HTML][HTML] Cellular circuits in the brain and their modulation in acute and chronic pain
Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …
[HTML][HTML] Role of the prefrontal cortex in pain processing
WY Ong, CS Stohler, DR Herr - Molecular neurobiology, 2019 - Springer
The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …
processing. The latter is dependent on its connections to other areas of the cerebral …
Resting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: A review and synthesis
This review synthesizes relations between mindfulness and resting-state fMRI functional
connectivity of brain networks. Mindfulness is characterized by present-moment awareness …
connectivity of brain networks. Mindfulness is characterized by present-moment awareness …
The link between depression and chronic pain: neural mechanisms in the brain
J Sheng, S Liu, Y Wang, R Cui, X Zhang - Neural plasticity, 2017 - Wiley Online Library
Chronic pain, as a stress state, is one of the critical factors for determining depression, and
their coexistence tends to further aggravate the severity of both disorders. Unfortunately …
their coexistence tends to further aggravate the severity of both disorders. Unfortunately …
[HTML][HTML] Targeted muscle reinnervation treats neuroma and phantom pain in major limb amputees: a randomized clinical trial
Objective: To compare targeted muscle reinnervation (TMR) to “standard treatment” of
neuroma excision and burying into muscle for postamputation pain. Summary Background …
neuroma excision and burying into muscle for postamputation pain. Summary Background …
[HTML][HTML] Chronic pain: structural and functional changes in brain structures and associated negative affective states
Chronic pain is a condition in which pain progresses from an acute to chronic state and
persists beyond the healing process. Chronic pain impairs function and decreases patients' …
persists beyond the healing process. Chronic pain impairs function and decreases patients' …