The most life-threatening aspects of the oncogenic process are invasion and metastasis.
Even though the clinical significance of such expression of the malignant phenotype has …

Notch signalling participates in the development of multicellular organisms by maintaining
the self-renewal potential of some tissues and inducing the differentiation of others …

Although Rat-l fibroblasts expressing c-myc constitutively are unable to arrest growth in low
serum, their numbers do not increase in culture because of substantial cell death. We show …

The Ras gene product is a monomeric membrane-localized G protein of 21 kd that functions
as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to …

A group of coordinated cellular processes, not just one gene product, is responsible for
invasion and metastasis, the most life-threatening aspect of cancer. It is now recognized that …

Publisher Summary This chapter focuses on the proteins of the Myc network that are
essential regulators of cell growth and differentiation. The identification of the Myc partner …

Although the ras genes have long been established as proto-oncogenes, the dominant role
of activated ras in cell transformation has been questioned. Previous studies have shown …

Constitutive expression of human MYC represses mRNA levels of cyclin Dl in proliferating
BALB/c-3T3 fibroblasts. We expressed a series of mutant alleles of MYC and found that …

Background. New measures enabling better prediction of biologic behavior of large bowel
cancer are highly desirable. One hundred ninety‐four consecutive primary, recurrent, and …

Molecular Biology of Cancer has been extensively revised and covers heredity cancer,
microarray technology and increased study of childhood cancers. It continues to provide a …