The CSF-1 receptor (CSF-1R) is activated by the homodimeric growth factors colony-
stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). It plays important roles in …

Abstract Purpose of Review Chronic non-bacterial osteomyelitis (CNO) with its most severe
form chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone …

All cellular compartments are separated from the external environment by a membrane,
which consists of a lipid bilayer. Subcellular structures, including clathrin-coated pits …

Actin filament assembly typically occurs in association with cellular membranes. A large
number of proteins sit at the interface between actin networks and membranes, playing …

Tension applied to the plasma membrane (PM) is a global mechanical parameter involved
in cell migration. However, how membrane tension regulates actin assembly is unknown …

Chronic nonbacterial osteomyelitis (CNO) is an inflammatory bone disorder that most
frequently affects children and adolescents. Chronic recurrent multifocal osteomyelitis …

How local interactions of actin regulators yield large-scale organization of cell shape and
movement is not well understood. Here we investigate how the WAVE complex organizes …

To control their movement, cells need to coordinate actin assembly with the geometric
features of their substrate. Here, we uncover a role for the actin regulator WASP in the 3D …

PSTPIP1 is a cytoskeletal adaptor and F-BAR protein that has been implicated in
autoinflammatory disease, most notably in the PAPA syndrome: pyogenic sterile arthritis …

Dendritic cells sample the environment for antigens and play an important role in
establishing the link between innate and acquired immunity. Dendritic cells contain …