Transfer RNAs (tRNAs) are central players in translation, functioning as adapter molecules
between the informational level of nucleic acids and the functional level of proteins. They …

Post-transcriptional ribonucleotide modification is a phenomenon best studied in tRNA,
where it occurs most frequently and in great chemical diversity. This paper reviews the …

Alternative foldings are an inherent property of RNA and a ubiquitous problem in scientific
investigations. To a living organism, alternative foldings can be a blessing or a problem, and …

As the adaptor that decodes mRNA sequence into protein, the basic aspects of tRNA
structure and function are central to all studies of biology. Yet the complexities of their …

Mature tRNA is normally extensively modified and extremely stable. Recent evidence
suggests that hypomodified mature tRNA in yeast can undergo a quality control check by a …

Despite the universality of tRNA modifications, some tRNAs lacking specific modifications
are subject to degradation pathways, while other tRNAs lacking the same modifications are …

In Escherichia coli, inconsistencies between in vitro tRNA aminoacylation measurements
and in vivo protein synthesis demands were postulated almost 40 years ago, but have …

A plethora of modified nucleotides extends the chemical and conformational space for
natural occurring RNAs. tRNAs constitute the class of RNAs with the highest modification …

Post-transcriptional nucleoside modifications fine-tune the biophysical and biochemical
properties of transfer RNA (tRNA) so that it is optimized for participation in cellular …

Compartmentalization of RNA in biopolymer-rich membraneless organelles is now
understood to be pervasive and critical for the function of extant biology and has been …