Statistical and methodological considerations for the interpretation of intranasal oxytocin studies

H Walum, ID Waldman, LJ Young - Biological psychiatry, 2016 - Elsevier
Over the last decade, oxytocin (OT) has received focus in numerous studies associating
intranasal administration of this peptide with various aspects of human social behavior …

Does oxytocin increase trust in humans? A critical review of research

G Nave, C Camerer… - … on Psychological Science, 2015 - journals.sagepub.com
Behavioral neuroscientists have shown that the neuropeptide oxytocin (OT) plays a key role
in social attachment and affiliation in nonhuman mammals. Inspired by this initial research …

[HTML][HTML] Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans

DA Martins, N Mazibuko, F Zelaya… - Nature …, 2020 - nature.com
Could nose-to-brain pathways mediate the effects of peptides such as oxytocin (OT) on brain
physiology when delivered intranasally? We address this question by contrasting two …

[HTML][HTML] Links between the neurobiology of oxytocin and human musicality

AR Harvey - Frontiers in human neuroscience, 2020 - frontiersin.org
The human species possesses two complementary, yet distinct, universal communication
systems—language and music. Functional imaging studies have revealed that some core …

Oxytocin delivered nasally or intraperitoneally reaches the brain and plasma of normal and oxytocin knockout mice

AS Smith, AC Korgan, WS Young - Pharmacological research, 2019 - Elsevier
Intranasal delivery of oxytocin (Oxt) has been identified as a potential therapeutic to target
human conditions characterized by social deficits, yet the ability of this administrative route …

Oxytocin and social functioning

C Jones, I Barrera, S Brothers, R Ring… - Dialogues in clinical …, 2017 - Taylor & Francis
Social anxiety is a form of anxiety characterized by continuous fear of one or more social or
performance situations. Although multiple treatment modalities (cognitive behavioral …

Social decision-making and the brain: A comparative perspective

S Tremblay, KM Sharika, ML Platt - Trends in cognitive sciences, 2017 - cell.com
The capacity and motivation to be social is a key component of the human adaptive
behavioral repertoire. Recent research has identified social behaviors remarkably similar to …

Agile delivery of protein therapeutics to CNS

X Yi, DS Manickam, A Brynskikh… - Journal of Controlled …, 2014 - Elsevier
A variety of therapeutic proteins have shown potential to treat central nervous system (CNS)
disorders. Challenge to deliver these protein molecules to the brain is well known. Proteins …

A review of oxytocin's effects on the positive, negative, and cognitive domains of schizophrenia

D Feifel, PD Shilling, K MacDonald - Biological psychiatry, 2016 - Elsevier
Schizophrenia is a disabling, heterogeneous disorder with clinical features that can be
parsed into three domains: positive symptoms, negative symptoms, and cognitive deficits …

Interplay between the oxytocin and opioid systems in regulating social behaviour

PT Putnam, SWC Chang - Philosophical Transactions of …, 2022 - royalsocietypublishing.org
The influence of neuromodulators on brain activity and behaviour is undeniably profound,
yet our knowledge of the underlying mechanisms, or ability to reliably reproduce effects …