An insight into the health-promoting effects of taxifolin (dihydroquercetin)

C Sunil, B Xu - Phytochemistry, 2019 - Elsevier
Abstract Taxifolin (3, 5, 7, 3, 4-pentahydroxy flavanone or dihydroquercetin) is a flavonoid
commonly found in onion, milk thistle, French maritime pine bark and Douglas fir bark. It is …

[HTML][HTML] The hallmarks of flavonoids in cancer

LGS Ponte, ICB Pavan, MCS Mancini, LGS da Silva… - Molecules, 2021 - mdpi.com
Flavonoids represent an important group of bioactive compounds derived from plant-based
foods and beverages with known biological activity in cells. From the modulation of …

Redox signaling by reactive electrophiles and oxidants

S Parvez, MJC Long, JR Poganik, Y Aye - Chemical reviews, 2018 - ACS Publications
The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Dihydroquercetin supplement alleviates colonic inflammation potentially through improved gut microbiota community in mice

F Wan, H Han, R Zhong, M Wang, S Tang, S Zhang… - Food & Function, 2021 - pubs.rsc.org
The purpose of the current study was to investigate the effect of dietary dihydroquercetin
(DHQ) supplementation on dextran sodium sulfate (DSS)-induced colitis in mice. Mice were …

[HTML][HTML] The role of epigenetic modifications in human cancers and the use of natural compounds as epidrugs: Mechanistic pathways and pharmacodynamic actions

A Bouyahya, H Mechchate, L Oumeslakht, I Zeouk… - Biomolecules, 2022 - mdpi.com
Cancer is a complex disease resulting from the genetic and epigenetic disruption of normal
cells. The mechanistic understanding of the pathways involved in tumor transformation has …

[HTML][HTML] Dihydroquercetin attenuates silica-induced pulmonary fibrosis by inhibiting ferroptosis signaling pathway

L Yuan, Y Sun, N Zhou, W Wu, W Zheng… - Frontiers in …, 2022 - frontiersin.org
Silicosis is a fatal occupational lung disease which currently has no effective treatment.
Dihydroquercetin (DHQ) is a flavonoid compound known for its anti-inflammatory, anti …

Bacterial biosynthesis of flavonoids: Overview, current biotechnology applications, challenges, and prospects

CO Okoye, H Jiang, Y Wu, X Li, L Gao… - Journal of Cellular …, 2023 - Wiley Online Library
Flavonoids are secondary metabolites present in plant organs and tissues. These natural
metabolites are the most prevalent and display a wide range of beneficial physiological …

Targeting the crosstalk between canonical Wnt/β-catenin and inflammatory signaling cascades: A novel strategy for cancer prevention and therapy

D Tewari, S Bawari, S Sharma, LK DeLiberto… - Pharmacology & …, 2021 - Elsevier
Emerging scientific evidence indicates that inflammation is a critical component of tumor
promotion and progression. Most cancers originate from sites of chronic irritation, infections …

[HTML][HTML] Epigenetic regulation of NRF2/KEAP1 by phytochemicals

S Bhattacharjee, RH Dashwood - Antioxidants, 2020 - mdpi.com
Epigenetics has provided a new dimension to our understanding of nuclear factor erythroid
2–related factor 2/Kelch-like ECH-associated protein 1 (human NRF2/KEAP1 and murine …

[HTML][HTML] Polyphenols in colorectal cancer: current state of knowledge including clinical trials and molecular mechanism of action

MN Alam, M Almoyad, F Huq - BioMed research international, 2018 - hindawi.com
Polyphenols have been reported to have wide spectrum of biological activities including
major impact on initiation, promotion, and progression of cancer by modulating different …