Methods of tissue decellularization used for preparation of biologic scaffolds and in vivo relevance

TJ Keane, IT Swinehart, SF Badylak - Methods, 2015 - Elsevier
Biologic scaffolds composed of extracellular matrix (ECM) are widely used in both preclinical
animal studies and in many clinical applications to repair and reconstruct tissues. Recently …

Bone regenerative medicine: classic options, novel strategies, and future directions

A Oryan, S Alidadi, A Moshiri, N Maffulli - Journal of orthopaedic surgery …, 2014 - Springer
This review analyzes the literature of bone grafts and introduces tissue engineering as a
strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; …

Decellularized allogeneic and xenogeneic tissue as a bioscaffold for regenerative medicine: factors that influence the host response

SF Badylak - Annals of biomedical engineering, 2014 - Springer
Biologic scaffold materials composed of mammalian extracellular matrix (ECM) are prepared
by decellularization of source tissues harvested from either humans (allogeneic) or a variety …

Evaluation of small intestine grafts decellularization methods for corneal tissue engineering

AC Oliveira, I Garzón, AM Ionescu, V Carriel… - PloS one, 2013 - journals.plos.org
Advances in the development of cornea substitutes by tissue engineering techniques have
focused on the use of decellularized tissue scaffolds. In this work, we evaluated different …

Flexor tendon tissue engineering: acellularization of human flexor tendons with preservation of biomechanical properties and biocompatibility

BC Pridgen, CYL Woon, M Kim, J Thorfinn… - … Engineering Part C …, 2011 - liebertpub.com
Objective: Acellular human tendons are a candidate scaffold for tissue engineering flexor
tendons of the hand. This study compared acellularization methods and their compatibility …

Decellularized and engineered tendons as biological substitutes: a critical review

AB Lovati, M Bottagisio, M Moretti - Stem cells international, 2016 - Wiley Online Library
Tendon ruptures are a great burden in clinics. Finding a proper graft material as a substitute
for tendon repair is one of the main challenges in orthopaedics, for which the requirement of …

Flexor tendon injuries

CS Klifto, JT Capo, A Sapienza, SS Yang… - JAAOS-Journal of the …, 2018 - journals.lww.com
Flexor tendon injuries of the hand are uncommon, and they are among the most challenging
orthopaedic injuries to manage. Proper management is essential to ensure optimal …

Tenogenic differentiation of equine adipose-tissue-derived stem cells under the influence of tensile strain, growth differentiation factors and various oxygen tensions

O Raabe, K Shell, D Fietz, C Freitag, A Ohrndorf… - Cell and tissue …, 2013 - Springer
Mesenchymal stem cells have become extremely interesting for regenerative medicine and
tissue engineering in the horse. Stem cell therapy has been proven to be a powerful and …

Human Flexor Tendon Tissue Engineering: Decellularization of Human Flexor Tendons Reduces Immunogenicity In Vivo

SS Raghavan, CYL Woon, A Kraus… - … Engineering Part A, 2012 - liebertpub.com
Background: In mutilating hand injuries, tissue engineered tendon grafts may provide a
reconstructive solution. We have previously described a method to decellularize cadaveric …

Decellularized tendon as a prospective scaffold for tendon repair

S Wang, Y Wang, L Song, J Chen, Y Ma, Y Chen… - Materials Science and …, 2017 - Elsevier
Tendon injuries impose significant clinical burdens on healthcare systems worldwide. At
present, no therapeutic methods can cure tendon injuries in an ideal manner. With the …