Novel N-Acyl Hydrazone Compounds as Promising Anticancer Agents: Synthesis and Molecular Docking Studies
Y Biliz, B Hasdemir, H Başpınar Küçük… - ACS …, 2023 - ACS Publications
In this study, a new series of N-acyl hydrazones 7a-e, 8a-e, and 9a-e, starting from methyl δ-
oxo pentanoate with different substituted groups 1a-e, were synthesized as anticancer …
oxo pentanoate with different substituted groups 1a-e, were synthesized as anticancer …
Synthesis and structure-activity relationship of elastase inhibiting novel ethylated thiazole-triazole acetamide hybrids: Mechanistic insights through kinetics and …
Keeping in mind the pharmacological importance of 2-aminothiazole and 1, 2, 4-triazole
heterocyclic moieties, a series of novel ethylated bi-heterocyclic acetamide hybrids, 9a–p …
heterocyclic moieties, a series of novel ethylated bi-heterocyclic acetamide hybrids, 9a–p …
Recent advances in the development of elastase inhibitors
B Donarska, KZ Łączkowski - Future Medicinal Chemistry, 2020 - Taylor & Francis
Human neutrophil elastase (HNE) is a serine proteinase of the chymotrypsin family, and
together with Pr3 and CatG belongs to the main NSPs. Neutrophil elastase is a 218 amino …
together with Pr3 and CatG belongs to the main NSPs. Neutrophil elastase is a 218 amino …
Synthesis and characterization of new 4H-chromene-3-carboxylates ensuring potent elastase inhibition activity along with their molecular docking and …
A new series of 4H-chromene-3-carboxylate derivatives were synthesized using
multicomponent reaction of salicylaldehyde, ethyl acetoacetate and dimedone in ethanol …
multicomponent reaction of salicylaldehyde, ethyl acetoacetate and dimedone in ethanol …
[HTML][HTML] Discovery of new 3, 3-diethylazetidine-2, 4-dione based thiazoles as nanomolar human neutrophil elastase inhibitors with broad-spectrum antiproliferative …
B Donarska, M Świtalska, J Wietrzyk… - International Journal of …, 2022 - mdpi.com
A series of 3, 3-diethylazetidine-2, 4-dione based thiazoles 3a–3j were designed and
synthesized as new human neutrophil elastase (HNE) inhibitors in nanomolar range. The …
synthesized as new human neutrophil elastase (HNE) inhibitors in nanomolar range. The …
Design and synthesis of thiadiazole-oxadiazole-acetamide derivatives: Elastase inhibition, cytotoxicity, kinetic mechanism, and computational studies
Considering the biological significance of 1, 3, 4-thiadiazole/oxadiazole heterocyclic
scaffolds, a novel series of 1, 3, 4-thiadiazole-1, 3, 4-oxadiazole-acetamide derivatives (7a …
scaffolds, a novel series of 1, 3, 4-thiadiazole-1, 3, 4-oxadiazole-acetamide derivatives (7a …
Human neutrophil elastase inhibitors: Classification, biological‐synthetic sources and their relevance in related diseases
JS Ocampo‐Gallego… - Fundamental & …, 2024 - Wiley Online Library
Background Human neutrophil elastase is a multifunctional protease enzyme whose
function is to break the bonds of proteins and degrade them to polypeptides or amino acids …
function is to break the bonds of proteins and degrade them to polypeptides or amino acids …
[PDF][PDF] Płazi nski
B Donarska, M Switalska, J Wietrzyk - Int. J. Mol. Sci, 2022 - academia.edu
A series of 3, 3-diethylazetidine-2, 4-dione based thiazoles 3a–3j were designed and
synthesized as new human neutrophil elastase (HNE) inhibitors in nanomolar range. The …
synthesized as new human neutrophil elastase (HNE) inhibitors in nanomolar range. The …