Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

M Xu, Y Qi, G Liu, Y Song, X Jiang, B Du - ACS nano, 2023 - ACS Publications
Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …

The in vivo fate of polymeric micelles

Y Cai, J Qi, Y Lu, H He, W Wu - Advanced Drug Delivery Reviews, 2022 - Elsevier
This review aims to provide a systemic analysis of the in vivo, as well as subcellular, fate of
polymeric micelles (PMs), starting from the entry of PMs into the body. Few PMs are able to …

[HTML][HTML] An update on oral drug delivery via intestinal lymphatic transport

Z Zhang, Y Lu, J Qi, W Wu - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Orally administered drug entities have to survive the harsh gastrointestinal environment,
penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the …

Towards more accurate bioimaging of drug nanocarriers: turning aggregation-caused quenching into a useful tool

J Qi, X Hu, X Dong, Y Lu, H Lu, W Zhao… - Advanced Drug Delivery …, 2019 - Elsevier
One of the current challenges in the monitoring of drug nanocarriers lies in the difficulties in
discriminating the carrier-bound signals from the bulk signals of probes. Environment …

One stone two birds: Multifunctional flavonol nanocrystals enable food packaging to both preserve freshness and visually monitor freshness

F Li, T Zhe, K Ma, Y Zhang, R Li, Y Cao, M Li… - Chemical Engineering …, 2023 - Elsevier
Food packaging with both active and intelligent components is critical for reducing food
waste and ensuring food safety. However, concerns about the toxicity of components or …

Biological and intracellular fates of drug nanocrystals through different delivery routes: Recent development enabled by bioimaging and PK modeling

Y Lv, W Wu, CD Corpstein, T Li, Y Lu - Advanced Drug Delivery Reviews, 2022 - Elsevier
Abstract Nanocrystals have contributed to exciting improvements in the delivery of poorly
water-soluble drugs. The biological and intracellular fates of nanocrystals are currently …

Drug nanocrystals: Fabrication methods and promising therapeutic applications

IS Mohammad, H Hu, L Yin, W He - International journal of pharmaceutics, 2019 - Elsevier
The drug nanocrystals (NCs) with unique physicochemical properties are now considered
as a promising drug delivery system for poorly water-soluble drugs. So far> 20 formulations …

Establishment of In Vitro Dissolution Based on Similarity with In Vivo Dissolution: A Case Study on Aripiprazole

F Man, Y Yang, H He, J Qi, W Wu… - Molecular Pharmaceutics, 2023 - ACS Publications
In vitro dissolution that predicts the in vivo performance of solid preparations is extremely
important in formulation optimization. Fraction absorbed (F a) has been used to screen in …

Utility of Pickering emulsions in improved oral drug delivery

Z Tai, Y Huang, Q Zhu, W Wu, T Yi, Z Chen, Y Lu - Drug Discovery Today, 2020 - Elsevier
Highlights•Properties of particle stabilizers are crucial to construct Pickering
emulsions.•Pickering emulsions enhance bioavailability or bioaccessibility of …

[HTML][HTML] Battle of the milky way: Lymphatic targeted drug delivery for pathogen eradication

A Taheri, KE Bremmell, P Joyce… - Journal of Controlled …, 2023 - Elsevier
Many viruses, bacteria, and parasites rely on the lymphatic system for survival, replication,
and dissemination. While conventional anti-infectives can combat infection-causing agents …