Although all the cells in an organism contain the same genetic information, differences in the
cell phenotype arise from the expression of lineage‐specific genes. During myelopoiesis …

In the hematopoietic system, lineage commitment and differentiation is controlled by the
combinatorial action of transcription factors from diverse families. SCL is a basic helix-loop …

The T cell leukemia oncoprotein SCL/tal-1, a basic–helix-loop-helix transcription factor, is
required for production of embryonic red blood cells in the mouse yolk sac. To define roles in …

Homozygosity for a null mutation in the scl gene causes mid‐gestational embryonic lethality
in the mouse due to failure of development of primitive hematopoiesis. Whilst this …

The distinct cell types of multicellular organisms arise owing to constraints imposed by gene
regulatory networks on the collective change of gene expression across the genome …

Hematopoiesis in the mouse conceptus begins in the visceral yolk (VYS), with primitive
erythroblasts first evident in blood islands at the headfold stage (E8. 0). VYS erythropoiesis …

The combinatorial interaction among transcription factors is believed to determine
hematopoietic cell fate. Stem cell leukemia (SCL, also known as TAL1 [T-cell acute …

Hematopoietic stem cells (HSCs) are characterized by their ability to execute a wide range
of cell fate choices, including self-renewal, quiescence, and differentiation into the many …

Combinations of hematopoietic cytokines and the ventral mesoderm inducer BMP-4 have
recently been shown to augment hematopoietic cell fate of human embryonic stem cells …

BEGINNING AT THE BEDSIDE: A CASE OF T-CELL LEUKEMIA THIS STORY BEGINS with
a seminal case report describ-ing a 16-year-old boy who presented with acute lymphoblastic …