Biomedical applications of nanomaterials in the advancement of nucleic acid therapy: mechanistic challenges, delivery strategies, and therapeutic applications

K Yadav, KK Sahu, SPE Gnanakani, P Sure… - International Journal of …, 2023 - Elsevier
In the past few decades, substantial advancement has been made in nucleic acid (NA)-
based therapies. Promising treatments include mRNA, siRNA, miRNA, and anti-sense DNA …

Research status and prospect of non-viral vectors based on siRNA: a review

L Tong, D Liu, Z Cao, N Zheng, C Mao, S Liu… - International journal of …, 2023 - mdpi.com
Gene therapy has attracted much attention because of its unique mechanism of action, non-
toxicity, and good tolerance, which can kill cancer cells without damaging healthy tissues …

Silica‐based nanoparticles for enzyme immobilization and delivery

L Zhao, Y Zhang, Y Yang, C Yu - Chemistry–An Asian Journal, 2022 - Wiley Online Library
Enzymes play an indispensable role in biosystems, catalyzing a variety of chemical and
biochemical reactions with exceptionally high efficiency and selectivity. These features …

Doxorubicin-loaded silica nanocomposites for cancer treatment

V Popova, Y Poletaeva, A Chubarov, D Pyshnyi… - Coatings, 2023 - mdpi.com
Silica nanoparticles (SiNPs) are a promising material for nanomedicine technology. SiNPs
are considered a powerful tool for drug delivery, functional coatings and films, and …

Immunological nanomaterials to combat cancer metastasis

Y Pan, J Cheng, Y Zhu, J Zhang, W Fan… - Chemical Society …, 2024 - pubs.rsc.org
Metastasis causes greater than 90% of cancer-associated deaths, presenting huge
challenges for detection and efficient treatment of cancer due to its high heterogeneity and …

Mesoporous silica nanoparticles enhance the anticancer efficacy of platinum (IV)-phenolate conjugates in breast cancer cell lines

I Predarska, M Saoud, D Drača, I Morgan, T Komazec… - Nanomaterials, 2022 - mdpi.com
The main reasons for the limited clinical efficacy of the platinum (II)-based agent cisplatin
include drug resistance and significant side effects. Due to their better stability, as well as the …

Development of a cancer nanovaccine to induce antigen-specific immune responses based on large-sized Porous silica nanoparticles

H Shin, S Kang, SY Chae, C Won… - ACS Applied Materials & …, 2023 - ACS Publications
Cancer vaccine is one of the immunotherapeutic strategies aiming to effectively deliver
cancer antigens to professional antigen-presenting cells such as dendritic cells (DCs) …

Tumor microenvironment-regulated nanoplatforms for the inhibition of tumor growth and metastasis in chemo-immunotherapy

X Yu, X Wang, A Yamazaki, X Li - Journal of Materials Chemistry B, 2022 - pubs.rsc.org
Chemotherapy is one of the major clinical anticancer therapies. However, its efficiency is
limited by many factors, including the complex tumor microenvironment (TME). Herein …

Emerging Targets and Therapeutics in Immuno-Oncology: Insights from Landscape Analysis

KA Iyer, J Ivanov, R Tenchov, K Ralhan… - Journal of Medicinal …, 2024 - ACS Publications
In the ever-evolving landscape of cancer research, immuno-oncology stands as a beacon of
hope, offering novel avenues for treatment. This study capitalizes on the vast repository of …

The quest for nanoparticle-powered vaccines in cancer immunotherapy

Z Sun, H Zhao, L Ma, Y Shi, M Ji, X Sun, D Ma… - Journal of …, 2024 - Springer
Despite recent advancements in cancer treatment, this disease still poses a serious threat to
public health. Vaccines play an important role in preventing illness by preparing the body's …