The genetic basis of major depression

KM Kendall, E Van Assche, TFM Andlauer… - Psychological …, 2021 - cambridge.org
Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …

Personalized medicine and the power of electronic health records

NS Abul-Husn, EE Kenny - Cell, 2019 - cell.com
Personalized medicine has largely been enabled by the integration of genomic and other
data with electronic health records (EHRs) in the United States and elsewhere. Increased …

[HTML][HTML] ABO genotype alters the gut microbiota by regulating GalNAc levels in pigs

H Yang, J Wu, X Huang, Y Zhou, Y Zhang, M Liu, Q Liu… - Nature, 2022 - nature.com
The composition of the intestinal microbiome varies considerably between individuals and is
correlated with health. Understanding the extent to which, and how, host genetics …

Electronic health records and polygenic risk scores for predicting disease risk

R Li, Y Chen, MD Ritchie, JH Moore - Nature Reviews Genetics, 2020 - nature.com
Accurate prediction of disease risk based on the genetic make-up of an individual is
essential for effective prevention and personalized treatment. Nevertheless, to date …

The genetic basis for adult onset glaucoma: recent advances and future directions

Z Wang, JL Wiggs, T Aung, AP Khawaja… - Progress in Retinal and …, 2022 - Elsevier
Glaucoma, a diverse group of eye disorders that results in the degeneration of retinal
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …

Obesity and eating behavior from the perspective of twin and genetic research

K Silventoinen, H Konttinen - Neuroscience & biobehavioral reviews, 2020 - Elsevier
Obesity has dramatically increased during the last decades and is currently one of the most
serious global health problems. We present a hypothesis that obesity is a neuro-behavioral …

Genome-wide association meta-analysis yields 20 loci associated with gallstone disease

E Ferkingstad, A Oddsson, S Gretarsdottir… - Nature …, 2018 - nature.com
Gallstones are responsible for one of the most common diseases in the Western world and
are commonly treated with cholecystectomy. We perform a meta-analysis of two genome …

Estimating the heritability of SARS-CoV-2 susceptibility and COVID-19 severity

KLR Brown, V Ramlall, M Zietz, U Gisladottir… - Nature …, 2024 - nature.com
SARS-CoV-2 has infected over 340 million people, prompting therapeutic research. While
genetic studies can highlight potential drug targets, understanding the heritability of SARS …

Medical records-based chronic kidney disease phenotype for clinical care and “big data” observational and genetic studies

N Shang, A Khan, F Polubriaginof, F Zanoni… - Npj Digital …, 2021 - nature.com
Abstract Chronic Kidney Disease (CKD) represents a slowly progressive disorder that is
typically silent until late stages, but early intervention can significantly delay its progression …

Major depressive disorder: existing hypotheses about pathophysiological mechanisms and new genetic findings

M Kamran, F Bibi, A ur. Rehman, DW Morris - Genes, 2022 - mdpi.com
Major depressive disorder (MDD) is a common mental disorder generally characterized by
symptoms associated with mood, pleasure and effectiveness in daily life activities. MDD is …