Over the last thirty years, evidence has been accumulating that Hypertensive Disorders of
Pregnancy (HDP) and, specifically, Preeclampsia (PE) produce not only long-term effects on …

The placenta is a multifunctional organ that regulates key aspects of pregnancy
maintenance and fetal development. As the placenta is in direct contact with maternal blood …

Placental health is a key component to a successful pregnancy. Placental insufficiency (PI),
inadequate nutrient delivery to the fetus, is associated with preeclampsia (PE), a maternal …

Preeclampsia is a common obstetrical complication, hallmarked by new-onset hypertension.
Believed to result from placental insufficiency and chronic placental ischemia, the symptoms …

The application of genomic approaches to placental research has opened exciting new
avenues to help us understand basic biological properties of the placenta, improve prenatal …

Introduction Telomere length (TL) has been suggested to be influenced by inherited genetic
and epigenetic variation, hormonal effects, oxidative stress and age. However, the dynamics …

The placenta is a crucial organ for supporting a healthy pregnancy, and defective
development or function of the placenta is implicated in a number of complications of …

Preeclampsia (PE) is categorized as a pregnancy-related hypertensive disorder and is a
serious concern in pregnancies. Several factors, including genetic factors (placenta gene …

DNA methylation (DNAm), a mitotically stable epigenetic mark, can influence as well as
reflect gene expression. DNAm has been gaining interest for use as a biomarker for many …

Aim: To provide insight into fetal nucleated red blood cell (nRBC) development using
genome-wide DNA methylation (DNAm) profiling. Materials & methods: The DNAm profile …