Internal membrane bound structures sequester all genetic material in eukaryotic cells. The
most prominent of these structures is the nucleus, which is bounded by a double membrane …

The eukaryotic nucleus is surrounded by a protective nuclear envelope, which is perforated
by trafficking machines termed nuclear pore complexes (NPCs). The NPCs are the sole …

Passive macromolecular diffusion through nuclear pore complexes (NPCs) is thought to
decrease dramatically beyond a 30–60-kD size threshold. Using thousands of independent …

The toxic proline: arginine (PRn) poly-dipeptide encoded by the (GGGGCC) n repeat
expansion in the C9orf72 form of heritable amyotrophic lateral sclerosis (ALS) binds to the …

Nuclear pore complexes (NPCs) restrict the nucleocytoplasmic flux of most macromolecules,
but permit facilitated passage of nuclear transport receptors and their cargo complexes. We …

Nuclear pore complexes (NPCs) form aqueous conduits in the nuclear envelope and gate
the diffusion of large proteins between the cytoplasm and nucleoplasm. NPC proteins …

The exchange of molecules between the nucleus and cytoplasm is mediated through
nuclear pore complexes (NPCs) embedded in the nuclear envelope. Altering the …

Translocation through nuclear pore complexes (NPCs) requires interactions between
receptor–cargo complexes and phenylalanine-glycine (FG) repeats in multiple FG domain …

The karyopherin β (or importin β) family comprises soluble transport factors that mediate the
movement of proteins and RNAs between the nucleus and cytoplasm. Recent studies have …

The nuclear envelope is a physical barrier between the nucleus and cytoplasm and, as
such, separates the mechanisms of transcription from translation. This compartmentalization …