Alzheimer's disease [AD] is the most common cause of dementia in North America. Despite
30+ years of intense investigation, the field lacks consensus regarding the etiology and …

Alzheimer's disease (AD) is the most common form of dementia affecting elderly people. AD
is a multifaceted pathology characterized by accumulation of extracellular neuritic plaques …

Type 2 diabetes mellitus (T2DM) is common and increasing in prevalence worldwide, with
devastating public health consequences. While peripheral insulin resistance is a key feature …

Objective To identify plasma biomarkers for the diagnosis of Alzheimer disease (AD). Design
Baseline plasma screening of 151 multiplexed analytes combined with targeted biomarker …

Alzheimer's disease (AD) is the most common cause of dementia in North America. Growing
evidence supports the concept that AD is fundamentally a metabolic disease that results in …

Abstract Insulin and Insulin Growth Factor-1 (IGF-1) play a major role in body homeostasis
and glucose regulation. They also have paracrine/autocrine functions in the brain. The …

Objective: To relate serum insulin-like growth factor-1 (IGF-1) to risk of Alzheimer disease
(AD) dementia and to brain volumes in a dementia-free community sample spanning middle …

Objective Exaggerated central nervous system (CNS) inflammatory responses to peripheral
stressors may be implicated in delirium. This study hypothesised that the IL-1β family is …

Insulin, insulin-like growth factors (IGF) and their receptors are highly expressed in the adult
hippocampus. Thus, disturbances in the insulin-IGF signalling pathway may account for the …

Cerebrospinal fluid (CSF) bathes and cushions the brain; however, it also serves a major
role in the clearance of metabolic wastes and in the distribution of glucose, lipids, and amino …