Purpose: A systematic review was conducted to develop guidelines for radiotherapy in adult
patients with newly diagnosed malignant glioma. Methods: MEDLINE, CANCERLIT, the …

The incidence of glioblastoma (GBM) in the elderly population is slowly increasing in
Western countries. Current management includes surgery, radiation therapy (RT) and …

Purpose To prospectively compare standard radiation therapy (RT) with an abbreviated
course of RT in older patients with glioblastoma multiforme (GBM). Patients and Methods …

Objectives The optimal treatment for elderly patients (age> 70 years) with glioblastoma
remains controversial. We conducted a prospective trial in 32 consecutive elderly patients …

Median age at diagnosis in patients with glioblastoma (GB) is slowly increasing with an
aging population in Western countries, and was 64years in 2006. The number of patients …

BACKGROUND Elderly patients (age> 65 years) with glioblastoma multiforme frequently are
excluded from clinical studies, and prospective trials for patients with this age group do not …

Introduction Elderly patients have glioblastomas (GBM) that are aggressive and poorly
responsive to treatment. They are also prone to the side effects of treatment of GBM …

Epigenetic silencing of the O 6-methylguanine-DNA-methyltransferase (MGMT) gene by
promoter methylation is correlated with improved progression-free survival (PFS) and overall …

Purpose To evaluate 2 specific radiation schedules, each combined with temozolomide
(TMZ), assessing their efficacy and safety in patients aged≥ 65 years with newly diagnosed …

Objectives The optimal treatment for elderly patients (age> 70 years) with glioblastoma
(GBM) remains controversial. We conducted a prospective trial in 43 consecutive elderly …