[HTML][HTML] Harnessing knee joint resident mesenchymal stem cells in cartilage tissue engineering

X Xu, L Xu, J Xia, C Wen, Y Liang, Y Zhang - Acta Biomaterialia, 2023 - Elsevier
Osteoarthritis (OA) is a widespread clinical disease characterized by cartilage degeneration
in middle-aged and elderly people. Currently, there is no effective treatment for OA apart …

Temporomandibular joint osteoarthritis: pathogenic mechanisms involving the cartilage and subchondral bone, and potential therapeutic strategies for joint …

A Cardoneanu, LA Macovei, AM Burlui… - International Journal of …, 2022 - mdpi.com
The temporomandibular joint (TMJ) is a specialized synovial joint that is crucial for the
movement and function of the jaw. TMJ osteoarthritis (TMJ OA) is the result of disc …

LncRNA WDR11-AS1 promotes extracellular matrix synthesis in osteoarthritis by directly interacting with RNA-binding protein PABPC1 to stabilize SOX9 expression

H Huang, J Yan, X Lan, Y Guo, M Sun, Y Zhao… - International Journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is a degenerative disease of articular cartilage that is mainly
characterized by chronic and mild inflammation of the joints. Recently, many studies have …

Ethanolic Extract of Propolis Modulates Autophagy-Related microRNAs in Osteoarthritic Chondrocytes

C Arias, LA Salazar - International Journal of Molecular Sciences, 2023 - mdpi.com
Osteoarthritis is a multifactorial joint disease characterized by degeneration, and aging
stands as a significant risk factor. Autophagy, a crucial cellular homeostasis mechanism, is …

Copper (II) complexes with carnosine conjugates of hyaluronic acids at different dipeptide loading percentages behave as multiple SOD mimics and stimulate Nrf2 …

F Bellia, V Lanza, I Naletova, B Tomasello… - Antioxidants, 2023 - mdpi.com
A series of copper (II) complexes with the formula [Cu2+ Hy (x) Car%] varying the molecular
weight (MW) of Hyaluronic acid (Hy, x= 200 or 700 kDa) conjugated with carnosine (Car) …

[HTML][HTML] Engineered human osteoarthritic cartilage organoids

L Dönges, A Damle, A Mainardi, T Bock… - Biomaterials, 2024 - Elsevier
The availability of human cell-based models capturing molecular processes of cartilage
degeneration can facilitate development of disease-modifying therapies for osteoarthritis [1] …

[HTML][HTML] Cellular and tissue selectivity of AAV serotypes for gene delivery to chondrocytes and cartilage

DS Yoon, KM Lee, S Cho, EA Ko, J Kim… - … Journal of Medical …, 2021 - ncbi.nlm.nih.gov
Background: Despite several studies on the effect of adeno-associated virus (AAV)-based
therapeutics on osteoarthritis (OA), information on the transduction efficiency and applicable …

Emerging Landscape of In Vitro Models for Assessing Rheumatoid Arthritis Management

AP Mishra, R Kumar, S Harilal, M Nigam… - ACS Pharmacology & …, 2024 - ACS Publications
Rheumatoid arthritis (RA) is a complex condition that is influenced by various causes,
including immunological, genetic, and environmental factors. Several studies using animal …

Targeting the inflammatory hallmarks of obesity-associated osteoarthritis: Towards nutraceutical-oriented preventive and complementary therapeutic strategies based …

L Gambari, A Cellamare, F Grassi, B Grigolo… - International Journal of …, 2023 - mdpi.com
Obesity (Ob), which has dramatically increased in the last decade, is one of the main risk
factors that contribute to the incidence and progression of osteoarthritis (OA). Targeting the …

An in vitro engineered osteochondral model as tool to study osteoarthritis environment

A Scalzone, G Cerqueni, XN Wang… - Advanced …, 2023 - Wiley Online Library
Osteoarthritis (OA) is a joint degenerative pathology characterized by mechanical and
inflammatory damages affecting synovium, articular cartilage (AC), and subchondral bone …