The Earth turns on its axis every 24 h; almost all life on the planet has a mechanism—
circadian rhythmicity—to anticipate the daily changes caused by this rotation. The molecular …

Many features of the environment have been found to exert an important influence on
cardiovascular disease (CVD) risk, progression, and severity. Changes in the environment …

The circadian system, that is ubiquitous across species, generates∼ 24 h rhythms in
virtually all biological processes, and allows them to anticipate and adapt to the 24 h …

The importance of circadian biology has rarely been considered in pre-clinical studies, and
even more when translating to the bedside. Circadian biology is becoming a critical factor for …

Background On-pump cardiac surgery provokes a predictable perioperative myocardial
ischaemia–reperfusion injury which is associated with poor clinical outcomes. We …

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

Circadian clocks are encoded by a transcription-translation feedback loop that aligns
energetic processes with the solar cycle. We show that genetic disruption of the clock …

Myocardial ischemia reperfusion injury contributes to adverse cardiovascular outcomes after
myocardial ischemia, cardiac surgery or circulatory arrest. Primarily, no blood flow to the …

Inflammation not only plays a crucial role in acute ischemic cardiac injury, but also
contributes to post-infarction repair and remodeling. Traditionally, neutrophils have been …

Driven by autonomous molecular clocks that are synchronized by a master pacemaker in the
suprachiasmatic nucleus, cardiac physiology fluctuates in diurnal rhythms that can be partly …