This review explores the multifaceted role that iron has in cancer biology. Epidemiological
studies have demonstrated an association between excess iron and increased cancer …

Macrophages and neutrophils play a decisive role in host responses to intracellular bacteria
including the agent of tuberculosis (TB), M ycobacterium tuberculosis as they represent the …

Maintaining physiologic iron concentrations in tissues is critical for metabolism and host
defense. Iron absorption in the duodenum, recycling of iron from senescent erythrocytes …

Ferritin, a major iron storage protein, is essential to iron homeostasis and is involved in a
wide range of physiologic and pathologic processes. In clinical medicine, ferritin is …

For many years, hereditary hemochromatosis was regarded as a clinically and genetically
unique entity marked by a classic presentation consisting of diabetes, bronze skin …

Transition metals are required cofactors for many proteins that are critical for life, and their
concentration within cells is carefully maintained to avoid both deficiency and toxicity. To …

Oh what a difference a decade makes! In a landmark paper published in 1996, Feder and
colleagues identified the long-sought gene mutated in patients with classical hereditary …

Background Iron overload and hemochromatosis are common, treatable conditions. HFE
genotypes, levels of serum ferritin, transferrin saturation values, and self-reported medical …

Ferroportin exports iron into plasma from absorptive enterocytes, erythrophagocytosing
macrophages, and hepatic stores. The hormone hepcidin controls cellular iron export and …

Adult humans have about 25 trillion red blood cells (RBCs), and each second we recycle
about 5 million RBCs by erythrophagocytosis (EP) in macrophages of the reticuloendothelial …