An overview of targeted Therapies in acute myeloid leukemia
S Turkalj, FA Radtke, P Vyas - Hemasphere, 2023 - journals.lww.com
Acute myeloid leukemia (AML) is the most aggressive adult leukemia, characterized by
clonal differentiation arrest of progenitor or precursor hematopoietic cells. Intense preclinical …
clonal differentiation arrest of progenitor or precursor hematopoietic cells. Intense preclinical …
Mapping genotypes to chromatin accessibility profiles in single cells
In somatic tissue differentiation, chromatin accessibility changes govern priming and
precursor commitment towards cellular fates,–. Therefore, somatic mutations are likely to …
precursor commitment towards cellular fates,–. Therefore, somatic mutations are likely to …
Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging
Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSC) acquire mutations
in genes, including DNMT3A and TET2, conferring a competitive advantage through a …
in genes, including DNMT3A and TET2, conferring a competitive advantage through a …
Precise single-cell transcriptomic mapping of normal and leukemic cell states reveals unconventional lineage priming in acute myeloid leukemia
Initial classification of acute leukemia involves the assignment of blasts to cell states within
the hematopoietic hierarchy based on morphological and immunophenotypic features. Yet …
the hematopoietic hierarchy based on morphological and immunophenotypic features. Yet …
[HTML][HTML] A protocol for simultaneous high-sensitivity genotyping and chromatin accessibility profiling in single cells
S Turkalj, NA Jakobsen, A Groom, FA Radtke, P Vyas - STAR protocols, 2023 - Elsevier
Single-cell assay for transposase-accessible chromatin with sequencing (scATAC-seq)
resolves the heterogeneity of epigenetic states across cells but does not typically capture …
resolves the heterogeneity of epigenetic states across cells but does not typically capture …
Single-cell genotype-phenotype mapping identifies therapeutic vulnerabilities in VEXAS syndrome
Somatic evolution leads to the emergence of clonal diversity across tissues with broad
implications for human health. A striking example of somatic evolution is the VEXAS …
implications for human health. A striking example of somatic evolution is the VEXAS …