Peroxisomes carry out various oxidative reactions that are tightly regulated to adapt to the
changing needs of the cell and varying external environments. Accordingly, they are …

Peroxisomes are unique among the organelles of the endomembrane system. Unlike other
organelles that derive most if not all of their proteins from the ER (endoplasmic reticulum) …

Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal enzymes are imported from the cytosol by the receptor PEX5, which …

The peroxisomal protein import machinery differs fundamentally from known translocons
(endoplasmic reticulum, mitochondria, chloroplasts, bacteria) as it allows membrane …

Peroxisomes transport folded and oligomeric proteins across their membrane. Two cytosolic
import receptors, Pex5p and Pex7p, along with approximately 12 membrane-bound …

Peroxisomal targeting signals (PTSs) are recognized by predominantly cytosolic receptors,
Pex5p and Pex7p. The fate of these PTS receptors following their interactions on the …

The proper distribution of proteins between the cytosol and various membrane-bound
compartments is crucial for the functionality of eukaryotic cells. This requires the cooperation …

Peroxisomes are vital metabolic organelles that import their lumenal (matrix) enzymes from
the cytosol using mobile receptors. Surprisingly, the receptors can even import folded …

Peroxisomes import folded, even oligomeric, proteins, which distinguishes the peroxisomal
translocation machinery from the well-characterized translocons of other organelles. How …

The peroxisome biogenesis disorders (PBDs) comprise 12 autosomal recessive
complementation groups (CGs). The multisystem clinical phenotype varies widely in severity …