Cells and organisms must coordinate their metabolic activity with changes in their
environment to ensure their growth only when conditions are favourable. In order to maintain …

The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a
variety of environmental cues to regulate organismal growth and homeostasis. The pathway …

Flux through metabolic pathways is inherently sensitive to the levels of specific substrates
and products, but cellular metabolism is also managed by integrated control mechanisms …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility
of intracellular structures. Although F-actin is traditionally considered to be cytoplasmic, here …

Cancer cells characterized by uncontrolled growth and proliferation require altered
metabolic processes to maintain this characteristic. Metabolic reprogramming is a process …

The kinase mTOR (mechanistic target of rapamycin) integrates diverse environmental
signals and translates these cues into appropriate cellular responses. mTOR forms the …

The study of normal mammalian cell growth and the defects that contribute to disease
pathogenesis links metabolism to cell growth. Here, we visit several aspects of growth …

The mammalian target of rapamycin (mTOR) is a conserved protein kinase involved in a
multitude of cellular processes including cell growth. Increased mTOR activation is observed …

Insulin resistance and other features of the metabolic syndrome are increasingly recognized
for their effects on cognitive health. To ascertain mechanisms by which this occurs, we fed …