Background Mutation of BRAF is a predominant event in cancers with poor prognosis such
as melanoma and colorectal cancer. BRAF mutation leads to a constitutive activation of …

Telomeres, repetitive DNA sequences found at the ends of linear chromosomes, play a role
in regulating cellular proliferation, and shorten with increasing age in proliferating human …

Genomic instability is a characteristic of most cancer cells. It is an increased tendency of
genome alteration during cell division. Cancer frequently results from damage to multiple …

Abstracts Alzheimer's disease (AD) is a complex neurodegenerative disease characterized
by cognitive and short-term memory impairments. The disease involves multiple …

Purpose: In-depth characterization of recurrent glioblastoma (rGBM) might contribute to a
better understanding of the mechanisms behind tumor progression and enable rGBM …

STUDY QUESTION What are the relationships between telomere lengths in leukocytes and
sperm, sperm count and parents' age at conception in a group of apparently healthy subjects …

Telomeres, at the ends of chromosomes and strands of genetic material, become shorter as
cells divide in the process of aging. Telomere length has been considered as a biological …

Objective: Several pieces of evidence indicate that HIV-infected adults undergo premature
aging. The effect of HIV and antiretroviral therapy (ART) exposure on the aging process of …

Telomeres are protective nucleoprotein structures that cap linear chromosome ends and
safeguard genome stability. Progressive telomere shortening at each somatic cell division …

Background Telomere shortening, dysfunction, and fusion may facilitate the acquisition of
large-scale genomic rearrangements, driving clonal evolution and tumor progression. The …