Deaths from opioid use are increasing in the US, with a growing proportion due to synthetic
opioids. Until 2013, sporadic outbreaks of fentanyl and fentanyl analogs contaminating the …

Over the recent decades the interest in intranasal delivery as a non-invasive route for drugs
is increased. Since the nasal mucosa offers numerous benefits as a target tissue for drug …

Intranasal administration is a non-invasive route for drug delivery, which is widely used for
the local treatment of rhinitis or nasal polyposis. Since drugs can be absorbed into the …

As a non-invasive route, intranasal administration offers patient comfort and compliance
which are hurdled in parenteral drug therapy. In addition, the current recognition that the …

Background Many patients with lung cancer will develop symptoms related to their disease
process or the treatment they are receiving. These symptoms can be as debilitating as the …

Clinical studies comparing the response and side effects of various opioids have not been
able to show robust differences between drugs. Hence, recommendations of the regulatory …

Intranasal administration is an attractive option for local and systemic delivery of many
therapeutic agents. The nasal mucosa is–compared to other mucosae–easily accessible …

Fentanyl is a synthetic, highly selective opioid with many desirable physicochemical
properties, including a high lipophilicity and predictable pharmacokinetics. These properties …

Objective: The efficacy of intranasal fentanyl spray (INFS) was compared with that of oral
transmucosal fentanyl citrate (OTFC) for the relief of cancer-related breakthrough pain (BTP) …

Objective: This trial investigated the efficacy and long-term tolerability of intranasal fentanyl
spray (INFS) 50 to 200 μg in the treatment of breakthrough pain in opioid-tolerant patients …