Recently, the US Food and Drug Administration (FDA) approved the first chimeric antigen
receptor T cell (CAR-T) therapy for the treatment CD19-positive B cell acute lymphoblastic …

Occlusive arterial disease is a leading cause of morbidity and mortality worldwide. Aside
from balloon angioplasty, bypass graft surgery is the most commonly performed …

The therapeutic potential of CRISPR system has already been demonstrated in many
instances and begun to overlap with the rapidly expanding field of cancer immunotherapy …

Objective Aberrant expression of the immune checkpoint molecule, CD276, also known as
B7-H3, is associated with tumorigenesis. In this review, we aim to comprehensively describe …

Atherosclerosis is a chronic inflammatory disease that is initiated by the retention and
accumulation of cholesterol-containing lipoproteins, particularly low-density lipoprotein, in …

The field of immunotherapy is a continually expanding niche in cancer biology research. In
the last two decades, there has been significant progress in identifying better targets and …

Immune checkpoint inhibitor therapy has revolutionized the treatment of advanced
malignancies in recent years. Numerous reports have detailed the myriad of possible …

Both the chronic development of atherosclerotic lesions and the acute changes in lesion
phenotype that lead to clinical cardiovascular events are significantly influenced by the …

As the clinical applications of immune checkpoint inhibitors (ICIs) expand, our knowledge of
the potential adverse effects of these drugs continues to broaden. Emerging evidence …

Regulatory T cells (Tregs) play an important role in the regulation of T-cell–mediated
immune responses through suppression of T-cell proliferation and secretion of inhibitory …